Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates
Objective: This study investigated interleukin-10 and nitric oxide plasma levels following surgery to determine whether there is a correlation between these two variables and if different desflurane anesthesia flow rates influence nitric oxide and interleukin-10 concentrations in circulation. Materi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-07-01
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| Series: | Brazilian Journal of Anesthesiology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0104001413001474 |
| _version_ | 1811236273441996800 |
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| author | Dilek Kalaycı Bayazit Dikmen Murat Kaçmaz Vildan Taşpınar Dilşen Örnek Özlem Turan |
| author_facet | Dilek Kalaycı Bayazit Dikmen Murat Kaçmaz Vildan Taşpınar Dilşen Örnek Özlem Turan |
| author_sort | Dilek Kalaycı |
| collection | DOAJ |
| description | Objective: This study investigated interleukin-10 and nitric oxide plasma levels following surgery to determine whether there is a correlation between these two variables and if different desflurane anesthesia flow rates influence nitric oxide and interleukin-10 concentrations in circulation. Materials and methods: Forty patients between 18 and 70 years and ASA I–II physical status who were scheduled to undergo thyroidectomy were enrolled in the study. Interventions: Patients were allocated into two groups to receive two different desflurane anesthesia flow rates: high flow (Group HF) and low flow (Group LF). Measurements: Blood samples were drawn at the beginning (t0) and end (t1) of the operation and after 24 h (t2). Plasma interleukin-10 and nitric oxide levels were measured using an enzyme-linked-immunosorbent assay and a Griess reagents kit, respectively. Hemodynamic and respiratory parameters were assessed. Results: There was no statistically significant difference between the two groups with regard to interleukin-10 levels at the times of measurement. Interleukin-10 levels were increased equally in both groups at times t1 and t2 compared with preoperative concentrations. For both groups, nitric oxide circulating concentrations were significantly reduced at times t1 and t2 compared with preoperative concentrations. However, the nitric oxide value was lower for Group HF compared to Group LF at t2. No correlation was found between the IL-10 and nitric oxide levels. Conclusion: Clinical usage of two different flow anesthesia forms with desflurane may increase interleukin-10 levels both in Group HF and Group LF; nitric oxide levels circulating concentrations were significantly reduced at times t1 and t2 compared with preoperative concentrations; however, at 24 h postoperatively they were higher in Group LF compared to Group HF. No correlation was detected between interleukin-10 and nitric oxide levels. Resumo: Objetivo: este estudo investigou os níveis plasmáticos de interleucina-10 e óxido nítrico após cirurgia para determinar se há correlação entre essas duas variáveis e se diferentes taxas de fluxo de anestesia com desflurano influenciam as concentrações de interleucina-10 e óxido nítrico na circulação. Materiais e métodos: quarenta pacientes, entre 18 e 70 anos de idade, estado físico ASA I–II, programados para tireoidectomia foram incluídos no estudo. Intervenções: os pacientes foram divididos em dois grupos para receber dois fluxos diferentes de anestesia com desflurano: fluxo alto (Grupo FA) e fluxo baixo (Grupo FB). Mensurações: amostras de sangue foram colhidas no início (t0) e final (t1) da cirurgia e após 24 h (t2). Os níveis plasmáticos de interleucina-10 e óxido nítrico foram medidos usando um ensaio imunossorvente ligado à enzima um estojo de reagentes de Griess, respectivamente. Os parâmetros hemodinâmicos e respiratórios foram avaliados. Resultados: não houve diferença estatisticamente significante entre os dois grupos em relação aos níveis de interleucina-10 níveis nos tempos de medição. Os níveis de interleucina-10 aumentaram igualmente em ambos os grupos nos tempos t1 e t2 em comparação com as concentrações no pré-operatório. Em ambos os grupos, as concentrações circulantes de óxido nítrico estavam significativamente reduzidas nos tempos t1 e t2 em comparação com as concentrações no pré-operatório. No entanto, o valor de óxido nítrico foi menor no Grupo FA que no Grupo FB no t2. Não houve correlação entre os níveis de IL-10 e óxido nítrico. Conclusão: o uso clínico de dois fluxos diferentes em anestesia com desflurano pode aumentar os níveis de interleucina-10 tanto no Grupo FA quanto no Grupo FB; os níveis das concentrações circulantes de óxido nítrico estavam significativamente reduzidos nos tempos t1 e t2 em cmparação com as concentrações no pré-operatório; contudo, 24 h após a cirurgia, esses níveis estavam maiores no Grupo FB em relação ao Grupo FA. Não foi detectada correlação entre os níveis de interleucina-10 e óxido nítrico. Keywords: General anesthesia, Interleukin, Surgery, Nitricoxide, Desflurane, Palavras-chave: Anestesia geral, Interleucina, Cirurgia, Óxido nítrico, Desflurano |
| first_indexed | 2024-04-12T12:07:19Z |
| format | Article |
| id | doaj.art-e02a7e748b8441d3b2e43cbce27dc7f1 |
| institution | Directory Open Access Journal |
| issn | 0104-0014 |
| language | English |
| last_indexed | 2024-04-12T12:07:19Z |
| publishDate | 2014-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Anesthesiology |
| spelling | doaj.art-e02a7e748b8441d3b2e43cbce27dc7f12022-12-22T03:33:41ZengElsevierBrazilian Journal of Anesthesiology0104-00142014-07-01644292298Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow ratesDilek Kalaycı0Bayazit Dikmen1Murat Kaçmaz2Vildan Taşpınar3Dilşen Örnek4Özlem Turan5Department of Anaesthesia and Reanimation, Ankara Numune Training and Research Hospital, Ankara, TurkeyDepartment of Anaesthesia and Reanimation, Ankara Numune Training and Research Hospital, Ankara, TurkeyKırıkkale University, Medical Biochemistry Department, Kırıkkale, TurkeyDepartment of Anaesthesia and Reanimation, Ankara Numune Training and Research Hospital, Ankara, TurkeyDepartment of Anaesthesia and Reanimation, Ankara Numune Training and Research Hospital, Ankara, Turkey; Corresponding author.Department of Anaesthesia and Reanimation, Ankara Numune Training and Research Hospital, Ankara, TurkeyObjective: This study investigated interleukin-10 and nitric oxide plasma levels following surgery to determine whether there is a correlation between these two variables and if different desflurane anesthesia flow rates influence nitric oxide and interleukin-10 concentrations in circulation. Materials and methods: Forty patients between 18 and 70 years and ASA I–II physical status who were scheduled to undergo thyroidectomy were enrolled in the study. Interventions: Patients were allocated into two groups to receive two different desflurane anesthesia flow rates: high flow (Group HF) and low flow (Group LF). Measurements: Blood samples were drawn at the beginning (t0) and end (t1) of the operation and after 24 h (t2). Plasma interleukin-10 and nitric oxide levels were measured using an enzyme-linked-immunosorbent assay and a Griess reagents kit, respectively. Hemodynamic and respiratory parameters were assessed. Results: There was no statistically significant difference between the two groups with regard to interleukin-10 levels at the times of measurement. Interleukin-10 levels were increased equally in both groups at times t1 and t2 compared with preoperative concentrations. For both groups, nitric oxide circulating concentrations were significantly reduced at times t1 and t2 compared with preoperative concentrations. However, the nitric oxide value was lower for Group HF compared to Group LF at t2. No correlation was found between the IL-10 and nitric oxide levels. Conclusion: Clinical usage of two different flow anesthesia forms with desflurane may increase interleukin-10 levels both in Group HF and Group LF; nitric oxide levels circulating concentrations were significantly reduced at times t1 and t2 compared with preoperative concentrations; however, at 24 h postoperatively they were higher in Group LF compared to Group HF. No correlation was detected between interleukin-10 and nitric oxide levels. Resumo: Objetivo: este estudo investigou os níveis plasmáticos de interleucina-10 e óxido nítrico após cirurgia para determinar se há correlação entre essas duas variáveis e se diferentes taxas de fluxo de anestesia com desflurano influenciam as concentrações de interleucina-10 e óxido nítrico na circulação. Materiais e métodos: quarenta pacientes, entre 18 e 70 anos de idade, estado físico ASA I–II, programados para tireoidectomia foram incluídos no estudo. Intervenções: os pacientes foram divididos em dois grupos para receber dois fluxos diferentes de anestesia com desflurano: fluxo alto (Grupo FA) e fluxo baixo (Grupo FB). Mensurações: amostras de sangue foram colhidas no início (t0) e final (t1) da cirurgia e após 24 h (t2). Os níveis plasmáticos de interleucina-10 e óxido nítrico foram medidos usando um ensaio imunossorvente ligado à enzima um estojo de reagentes de Griess, respectivamente. Os parâmetros hemodinâmicos e respiratórios foram avaliados. Resultados: não houve diferença estatisticamente significante entre os dois grupos em relação aos níveis de interleucina-10 níveis nos tempos de medição. Os níveis de interleucina-10 aumentaram igualmente em ambos os grupos nos tempos t1 e t2 em comparação com as concentrações no pré-operatório. Em ambos os grupos, as concentrações circulantes de óxido nítrico estavam significativamente reduzidas nos tempos t1 e t2 em comparação com as concentrações no pré-operatório. No entanto, o valor de óxido nítrico foi menor no Grupo FA que no Grupo FB no t2. Não houve correlação entre os níveis de IL-10 e óxido nítrico. Conclusão: o uso clínico de dois fluxos diferentes em anestesia com desflurano pode aumentar os níveis de interleucina-10 tanto no Grupo FA quanto no Grupo FB; os níveis das concentrações circulantes de óxido nítrico estavam significativamente reduzidos nos tempos t1 e t2 em cmparação com as concentrações no pré-operatório; contudo, 24 h após a cirurgia, esses níveis estavam maiores no Grupo FB em relação ao Grupo FA. Não foi detectada correlação entre os níveis de interleucina-10 e óxido nítrico. Keywords: General anesthesia, Interleukin, Surgery, Nitricoxide, Desflurane, Palavras-chave: Anestesia geral, Interleucina, Cirurgia, Óxido nítrico, Desfluranohttp://www.sciencedirect.com/science/article/pii/S0104001413001474 |
| spellingShingle | Dilek Kalaycı Bayazit Dikmen Murat Kaçmaz Vildan Taşpınar Dilşen Örnek Özlem Turan Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates Brazilian Journal of Anesthesiology |
| title | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_full | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_fullStr | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_full_unstemmed | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_short | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_sort | plasma levels of interleukin 10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| url | http://www.sciencedirect.com/science/article/pii/S0104001413001474 |
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