The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency
The global prevalence of vitamin D deficiency is more than 20%, and the main causes include insufficient intake, reduced absorption, abnormal metabolism, or resistance to its effects. The levels of serum vitamin D appear to influence cardiovascular risk, and the mechanism involved is linked to the t...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/6/1239 |
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| author | Maria Barsan Anca Monica Brata Abdulrahman Ismaiel Dinu Iuliu Dumitrascu Andrei-Vlad Badulescu Traian Adrian Duse Stefana Dascalescu Stefan Lucian Popa Simona Grad Lucian Muresan Carmen Maria Maerescu Gabriel Cismaru Vlad Dumitru Brata |
| author_facet | Maria Barsan Anca Monica Brata Abdulrahman Ismaiel Dinu Iuliu Dumitrascu Andrei-Vlad Badulescu Traian Adrian Duse Stefana Dascalescu Stefan Lucian Popa Simona Grad Lucian Muresan Carmen Maria Maerescu Gabriel Cismaru Vlad Dumitru Brata |
| author_sort | Maria Barsan |
| collection | DOAJ |
| description | The global prevalence of vitamin D deficiency is more than 20%, and the main causes include insufficient intake, reduced absorption, abnormal metabolism, or resistance to its effects. The levels of serum vitamin D appear to influence cardiovascular risk, and the mechanism involved is linked to the transient outward current and the ultrarapid delayed rectifier K+ current densities, activated through the nuclear vitamin D receptor and Akt pathway. A significant number of studies have correlated vitamin D deficiency with an increased risk of developing cardiac arrhythmias and sudden cardiac death. For this reason, the purpose of this review is to analyze the relation between vitamin D deficiency and the pathogenesis of cardiac arrhythmias. Atrial fibrillation, increased QT interval, and QT dispersion were the most common findings associated with vitamin D deficiency. Due to the heterogeneity among existing studies, further research is necessary to confirm the existing data and to analyze its relationship with other types of arrhythmias. |
| first_indexed | 2024-03-10T00:22:16Z |
| format | Article |
| id | doaj.art-e02c21ef9f964d569ba0497e387352e8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:22:16Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e02c21ef9f964d569ba0497e387352e82023-11-23T15:41:20ZengMDPI AGBiomedicines2227-90592022-05-01106123910.3390/biomedicines10061239The Pathogenesis of Cardiac Arrhythmias in Vitamin D DeficiencyMaria Barsan0Anca Monica Brata1Abdulrahman Ismaiel2Dinu Iuliu Dumitrascu3Andrei-Vlad Badulescu4Traian Adrian Duse5Stefana Dascalescu6Stefan Lucian Popa7Simona Grad8Lucian Muresan9Carmen Maria Maerescu10Gabriel Cismaru11Vlad Dumitru Brata12Department of Occupational Health, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Environmental Protection, University of Oradea, 410048 Oradea, Romania2nd Medical Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaDepartment of Anatomy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania2nd Medical Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania2nd Medical Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaDepartment of Cardiology, ”Emile Muller” Hospital, 68200 Mulhouse, FranceDepartment of Obstetrics and Gynecology, “Filantropia” Clinical Municipal Hospital, 200136 Craiova, RomaniaFifth Department of Internal Medicine, Cardiology Rehabilitation, 400347 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaThe global prevalence of vitamin D deficiency is more than 20%, and the main causes include insufficient intake, reduced absorption, abnormal metabolism, or resistance to its effects. The levels of serum vitamin D appear to influence cardiovascular risk, and the mechanism involved is linked to the transient outward current and the ultrarapid delayed rectifier K+ current densities, activated through the nuclear vitamin D receptor and Akt pathway. A significant number of studies have correlated vitamin D deficiency with an increased risk of developing cardiac arrhythmias and sudden cardiac death. For this reason, the purpose of this review is to analyze the relation between vitamin D deficiency and the pathogenesis of cardiac arrhythmias. Atrial fibrillation, increased QT interval, and QT dispersion were the most common findings associated with vitamin D deficiency. Due to the heterogeneity among existing studies, further research is necessary to confirm the existing data and to analyze its relationship with other types of arrhythmias.https://www.mdpi.com/2227-9059/10/6/1239arrhythmiasatrial fibrillationvitamin D deficiencyhypovitaminosispathogenesissudden cardiac death |
| spellingShingle | Maria Barsan Anca Monica Brata Abdulrahman Ismaiel Dinu Iuliu Dumitrascu Andrei-Vlad Badulescu Traian Adrian Duse Stefana Dascalescu Stefan Lucian Popa Simona Grad Lucian Muresan Carmen Maria Maerescu Gabriel Cismaru Vlad Dumitru Brata The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency Biomedicines arrhythmias atrial fibrillation vitamin D deficiency hypovitaminosis pathogenesis sudden cardiac death |
| title | The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency |
| title_full | The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency |
| title_fullStr | The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency |
| title_full_unstemmed | The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency |
| title_short | The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency |
| title_sort | pathogenesis of cardiac arrhythmias in vitamin d deficiency |
| topic | arrhythmias atrial fibrillation vitamin D deficiency hypovitaminosis pathogenesis sudden cardiac death |
| url | https://www.mdpi.com/2227-9059/10/6/1239 |
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