Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents
A novel series of Schiff bases 4a–n was prepared from 2-hydrazinyl-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl) ethyl)acetamide. Thiazolidinone 5a–n derivatives were prepared from the reaction of Schiff base and thioglycolic acid. The structures of the synthesized compounds were assigned on the ba...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Arabian Journal of Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535212003000 |
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| author | Vinay Mahyavanshi Sunil I. Marjadi Rajaram Yadav |
| author_facet | Vinay Mahyavanshi Sunil I. Marjadi Rajaram Yadav |
| author_sort | Vinay Mahyavanshi |
| collection | DOAJ |
| description | A novel series of Schiff bases 4a–n was prepared from 2-hydrazinyl-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl) ethyl)acetamide. Thiazolidinone 5a–n derivatives were prepared from the reaction of Schiff base and thioglycolic acid. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and Mass spectral data. All the compounds were screened against different strains of bacteria and fungi. These active compounds impelled us to study their antitubercular activity. Compounds 4b, 5a, 5b, 5d, 5e, 5f, 5k, 5l and 5n emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 5k showed better antitubercular activity compared to Rifampicin. |
| first_indexed | 2024-04-13T07:38:27Z |
| format | Article |
| id | doaj.art-e02d41ff4169408f8f5e889f712b248b |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-13T07:38:27Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-e02d41ff4169408f8f5e889f712b248b2022-12-22T02:56:00ZengElsevierArabian Journal of Chemistry1878-53522017-02-0110S1S804S81310.1016/j.arabjc.2012.12.009Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agentsVinay Mahyavanshi0Sunil I. Marjadi1Rajaram Yadav2Department of Chemistry, KBS College, Vapi 396 195, IndiaDepartment of Chemistry, KBS College, Vapi 396 195, IndiaMicro Laboratory, Aarti Industries Ltd., (Custom Synthesis Division), Vapi 396 195, Gujarat, IndiaA novel series of Schiff bases 4a–n was prepared from 2-hydrazinyl-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl) ethyl)acetamide. Thiazolidinone 5a–n derivatives were prepared from the reaction of Schiff base and thioglycolic acid. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and Mass spectral data. All the compounds were screened against different strains of bacteria and fungi. These active compounds impelled us to study their antitubercular activity. Compounds 4b, 5a, 5b, 5d, 5e, 5f, 5k, 5l and 5n emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 5k showed better antitubercular activity compared to Rifampicin.http://www.sciencedirect.com/science/article/pii/S1878535212003000Schiff basesThiazolidinonesAntitubercularAntibacterialAntifungal activity |
| spellingShingle | Vinay Mahyavanshi Sunil I. Marjadi Rajaram Yadav Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents Arabian Journal of Chemistry Schiff bases Thiazolidinones Antitubercular Antibacterial Antifungal activity |
| title | Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents |
| title_full | Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents |
| title_fullStr | Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents |
| title_full_unstemmed | Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents |
| title_short | Synthesis and pharmacological studies of 1-(2-amino-1-(4-methoxyphenyl) ethyl) cyclohexanol analogs as potential microbial agents |
| title_sort | synthesis and pharmacological studies of 1 2 amino 1 4 methoxyphenyl ethyl cyclohexanol analogs as potential microbial agents |
| topic | Schiff bases Thiazolidinones Antitubercular Antibacterial Antifungal activity |
| url | http://www.sciencedirect.com/science/article/pii/S1878535212003000 |
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