Study of Serum Magnesium, Potassium and their Correlation with Lipid Profile in Ischaemic Heart Disease
Introduction: Ischaemic Heart Disease (IHD) is a common health burden. Dyslipidemia is an established risk factor for the disease. Studies have been conducted to evaluate any possible relation of the disease with alterations of magnesium and potassium. But, among patients of Eastern India, studi...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Pvt. Ltd.
2022-07-01
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Series: | National Journal of Laboratory Medicine |
Subjects: | |
Online Access: | https://www.njlm.net/articles/PDF/2625/53258_CE[Ra1]_F(SHU)_PF1(SG_KM_SHU)_redo_PFA(SHU)_PN(SHU).pdf |
Summary: | Introduction: Ischaemic Heart Disease (IHD) is a common health
burden. Dyslipidemia is an established risk factor for the disease.
Studies have been conducted to evaluate any possible relation
of the disease with alterations of magnesium and potassium.
But, among patients of Eastern India, studies to associate the
condition with these analytes as well as their possible relationship
with serum lipid profile have been rare.
Aim: To evaluate the non diabetic, normotensive IHD patients
attending a tertiary care hospital to find out whether there was
any association of the disease with altered serum Magnesium
(Mg) and Potassium (K) and to detect possible correlation of
these electrolytes with serum lipid levels.
Materials and Methods: This case-control study was conducted
in the Departments of Biochemistry and Medicine of the Institute
of Postgraduate Medical Education and Research, Kolkata, West
Bengal, India, from January 2019 to June 2020. This study included
106 non diabetic, normotensive IHD cases {encompassing 52
Chronic Coronary Syndrome (CCS) and 54 Acute Myocardial
Infarction (AMI) patients} along with 103 age and sex matched
healthy controls. Serum magnesium, potassium and lipid profiles
were assessed. Student’s unpaired t-test and Pearson correlation
tests were performed using Statistical Package for the Social
Sciences (SPSS) version 23 software.
Results: Mean age of the control and case groups were
63.95±7.94 and 63.60±7.56 years, respectively. The case and
control groups were comparable for age and gender distribution
as no statistically significant difference was found. The cases had
a significantly lower serum Mg and K (p<0.001 in each case) than
the controls. There were significant positive correlations between
serum Mg and K (r=0.498, p<0.001) while significant negative
correlations (r=-0.204, p=0.036) were established between
magnesium and low density lipoprotein cholesterol of the cases.
Conclusion: Low levels of serum magnesium and potassium are
associated with coronary heart disease. Patients with deranged
lipid profile should be regularly screened for deficiencies in
serum magnesium. Further longitudinal studies are warranted
to establish potential therapeutic role of supplementation of
magnesium and potassium in IHD |
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ISSN: | 2277-8551 2455-6882 |