Effect of Burn Injury on the Dissemination of Candida albicans from the Skin of Mouse
Burn injury is associated with the greatly increased susceptibility of thermally injured patients to infection from a variety of pathogens. Candida albicans is a commensal of skin and has been reported as a severe pathogen in thermally injured patients. Systemic candidiasis has emerged as a major ca...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Jinnah University for Women
2013-07-01
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| Series: | RADS Journal of Biological Research & Applied Science |
| Subjects: | |
| Online Access: | http://jbas.juw.edu.pk/index.php/JBAS/article/view/22 |
| _version_ | 1828259575128653824 |
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| author | Qudsia Hussain Amna Shafiq Shazia Tabassum Hakim Sayyada Ghufrana Nadeem |
| author_facet | Qudsia Hussain Amna Shafiq Shazia Tabassum Hakim Sayyada Ghufrana Nadeem |
| author_sort | Qudsia Hussain |
| collection | DOAJ |
| description | Burn injury is associated with the greatly increased susceptibility of thermally injured patients to infection from a variety of pathogens. Candida albicans is a commensal of skin and has been reported as a severe pathogen in thermally injured patients. Systemic candidiasis has emerged as a major cause of death in burn patients. In this study, the ability of Candida albicans to infect thermally injured host and the host response to systemic infections with Candida albicans was studied by using burned mice. The C. albicans suspension was spreaded over the burn surface. Mice were sacrificed ten days after burn to check the presence of yeasts in the kidneys, lung, liver and spleen or burn wounds. After 48 hr. of incubation of culture plates yeasts were recovered from the kidneys, lung, liver, spleen of burned mice. This study describes the enhanced susceptibility of burned mice to systemic candidiasis and shows that a systemic infection with Candida can lead organisms to contaminate the wound. |
| first_indexed | 2024-04-13T03:10:16Z |
| format | Article |
| id | doaj.art-e030a5695ae34d008c3711a60e71fa1b |
| institution | Directory Open Access Journal |
| issn | 2305-8722 2521-8573 |
| language | English |
| last_indexed | 2024-04-13T03:10:16Z |
| publishDate | 2013-07-01 |
| publisher | Jinnah University for Women |
| record_format | Article |
| series | RADS Journal of Biological Research & Applied Science |
| spelling | doaj.art-e030a5695ae34d008c3711a60e71fa1b2022-12-22T03:05:05ZengJinnah University for WomenRADS Journal of Biological Research & Applied Science2305-87222521-85732013-07-014222Effect of Burn Injury on the Dissemination of Candida albicans from the Skin of MouseQudsia Hussain0Amna Shafiq1Shazia Tabassum Hakim2Sayyada Ghufrana Nadeem3Jinnah University for Women, KarachiJinnah University for Women, KarachiJinnah University for Women, KarachiJinnah University for Women, KarachiBurn injury is associated with the greatly increased susceptibility of thermally injured patients to infection from a variety of pathogens. Candida albicans is a commensal of skin and has been reported as a severe pathogen in thermally injured patients. Systemic candidiasis has emerged as a major cause of death in burn patients. In this study, the ability of Candida albicans to infect thermally injured host and the host response to systemic infections with Candida albicans was studied by using burned mice. The C. albicans suspension was spreaded over the burn surface. Mice were sacrificed ten days after burn to check the presence of yeasts in the kidneys, lung, liver and spleen or burn wounds. After 48 hr. of incubation of culture plates yeasts were recovered from the kidneys, lung, liver, spleen of burned mice. This study describes the enhanced susceptibility of burned mice to systemic candidiasis and shows that a systemic infection with Candida can lead organisms to contaminate the wound.http://jbas.juw.edu.pk/index.php/JBAS/article/view/22Burn patientsCandida albicansCandidiasisSwiss albino miceThermal injury |
| spellingShingle | Qudsia Hussain Amna Shafiq Shazia Tabassum Hakim Sayyada Ghufrana Nadeem Effect of Burn Injury on the Dissemination of Candida albicans from the Skin of Mouse RADS Journal of Biological Research & Applied Science Burn patients Candida albicans Candidiasis Swiss albino mice Thermal injury |
| title | Effect of Burn Injury on the Dissemination of Candida albicans from the Skin of Mouse |
| title_full | Effect of Burn Injury on the Dissemination of Candida albicans from the Skin of Mouse |
| title_fullStr | Effect of Burn Injury on the Dissemination of Candida albicans from the Skin of Mouse |
| title_full_unstemmed | Effect of Burn Injury on the Dissemination of Candida albicans from the Skin of Mouse |
| title_short | Effect of Burn Injury on the Dissemination of Candida albicans from the Skin of Mouse |
| title_sort | effect of burn injury on the dissemination of candida albicans from the skin of mouse |
| topic | Burn patients Candida albicans Candidiasis Swiss albino mice Thermal injury |
| url | http://jbas.juw.edu.pk/index.php/JBAS/article/view/22 |
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