Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cells
Rice sprouts are reported to have potential as a functional food agent for health promotion, but studies on the biological activity of rice sprouts are insufficient. Thus, in this study, we investigated whether WERS exhibits immunostimulatory activity in macrophages. WERS increased the production of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Food and Agricultural Immunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09540105.2021.1947989 |
| _version_ | 1828884844860407808 |
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| author | Na Gyeong Geum Joo Ho Yeo Ju Hyeong Yu Min Yeong Choi Jae Won Lee Jueng Kyu Baek Jin Boo Jeong |
| author_facet | Na Gyeong Geum Joo Ho Yeo Ju Hyeong Yu Min Yeong Choi Jae Won Lee Jueng Kyu Baek Jin Boo Jeong |
| author_sort | Na Gyeong Geum |
| collection | DOAJ |
| description | Rice sprouts are reported to have potential as a functional food agent for health promotion, but studies on the biological activity of rice sprouts are insufficient. Thus, in this study, we investigated whether WERS exhibits immunostimulatory activity in macrophages. WERS increased the production of immunomodulatory factors such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in RAW264.7 cells. In addition, WERS activated the phagocytosis of RAW264.7 cells. The inhibition of toll-like receptor 2 (TLR2) and toll-like receptor 4 (TLR4) blocked WERS-mediated production of immunomodulatory factors in RAW264.7 cells. In addition, the inhibition of p38 and JNK suppressed the production of immunomodulatory factors by WERS, and the activation of p38 and JNK was blocked by the inhibition of TLR2 and TLR4. Taken together, WERS induced macrophage activation through TLR2/4-dependent activation of p38 and JNK. |
| first_indexed | 2024-12-13T11:15:46Z |
| format | Article |
| id | doaj.art-e033d57fb55e49f9a4421b8dda5a0a03 |
| institution | Directory Open Access Journal |
| issn | 0954-0105 1465-3443 |
| language | English |
| last_indexed | 2024-12-13T11:15:46Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Food and Agricultural Immunology |
| spelling | doaj.art-e033d57fb55e49f9a4421b8dda5a0a032022-12-21T23:48:37ZengTaylor & Francis GroupFood and Agricultural Immunology0954-01051465-34432021-01-0132134935910.1080/09540105.2021.19479891947989Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cellsNa Gyeong Geum0Joo Ho Yeo1Ju Hyeong Yu2Min Yeong Choi3Jae Won Lee4Jueng Kyu Baek5Jin Boo Jeong6Andong National UniversityAndong National UniversityAndong National UniversityAndong National UniversityAgricultural Corporation E·Farm Corp.Andong National UniversityAndong National UniversityRice sprouts are reported to have potential as a functional food agent for health promotion, but studies on the biological activity of rice sprouts are insufficient. Thus, in this study, we investigated whether WERS exhibits immunostimulatory activity in macrophages. WERS increased the production of immunomodulatory factors such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in RAW264.7 cells. In addition, WERS activated the phagocytosis of RAW264.7 cells. The inhibition of toll-like receptor 2 (TLR2) and toll-like receptor 4 (TLR4) blocked WERS-mediated production of immunomodulatory factors in RAW264.7 cells. In addition, the inhibition of p38 and JNK suppressed the production of immunomodulatory factors by WERS, and the activation of p38 and JNK was blocked by the inhibition of TLR2 and TLR4. Taken together, WERS induced macrophage activation through TLR2/4-dependent activation of p38 and JNK.http://dx.doi.org/10.1080/09540105.2021.1947989immunostimulatory activitymacrophagesricerice sproutssprouts |
| spellingShingle | Na Gyeong Geum Joo Ho Yeo Ju Hyeong Yu Min Yeong Choi Jae Won Lee Jueng Kyu Baek Jin Boo Jeong Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cells Food and Agricultural Immunology immunostimulatory activity macrophages rice rice sprouts sprouts |
| title | Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cells |
| title_full | Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cells |
| title_fullStr | Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cells |
| title_full_unstemmed | Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cells |
| title_short | Rice sprouts exert immunostimulatory activity in mouse macrophages, RAW264.7 cells |
| title_sort | rice sprouts exert immunostimulatory activity in mouse macrophages raw264 7 cells |
| topic | immunostimulatory activity macrophages rice rice sprouts sprouts |
| url | http://dx.doi.org/10.1080/09540105.2021.1947989 |
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