1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade
The α-arylation of amides via aryl migration has attracted considerable interest in recent years. Here, the authors report a method for the preparation of bulky α-quaternary amides via a polar-radical crossover enolate oxidation-aryl migration cascade.
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Format: | Article |
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Nature Portfolio
2022-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-30817-3 |
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author | Niklas Radhoff Armido Studer |
author_facet | Niklas Radhoff Armido Studer |
author_sort | Niklas Radhoff |
collection | DOAJ |
description | The α-arylation of amides via aryl migration has attracted considerable interest in recent years. Here, the authors report a method for the preparation of bulky α-quaternary amides via a polar-radical crossover enolate oxidation-aryl migration cascade. |
first_indexed | 2024-04-12T18:05:42Z |
format | Article |
id | doaj.art-e035ca43aa4f40e3b70e6d5d56e48109 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-04-12T18:05:42Z |
publishDate | 2022-06-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-e035ca43aa4f40e3b70e6d5d56e481092022-12-22T03:22:00ZengNature PortfolioNature Communications2041-17232022-06-0113111010.1038/s41467-022-30817-31,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascadeNiklas Radhoff0Armido Studer1Organisch-Chemisches Institut, Westfälische Wilhelms-UniversitätOrganisch-Chemisches Institut, Westfälische Wilhelms-UniversitätThe α-arylation of amides via aryl migration has attracted considerable interest in recent years. Here, the authors report a method for the preparation of bulky α-quaternary amides via a polar-radical crossover enolate oxidation-aryl migration cascade.https://doi.org/10.1038/s41467-022-30817-3 |
spellingShingle | Niklas Radhoff Armido Studer 1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade Nature Communications |
title | 1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade |
title_full | 1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade |
title_fullStr | 1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade |
title_full_unstemmed | 1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade |
title_short | 1,4-Aryl migration in ketene-derived enolates by a polar-radical-crossover cascade |
title_sort | 1 4 aryl migration in ketene derived enolates by a polar radical crossover cascade |
url | https://doi.org/10.1038/s41467-022-30817-3 |
work_keys_str_mv | AT niklasradhoff 14arylmigrationinketenederivedenolatesbyapolarradicalcrossovercascade AT armidostuder 14arylmigrationinketenederivedenolatesbyapolarradicalcrossovercascade |