Stem cell membrane-coated isotretinoin for acne treatment
Abstract Background Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers wi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-020-00664-9 |
| _version_ | 1818013505526169600 |
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| author | Shiyi Wang Rihua Jiang Tianqi Meng Fuqiang Zhang Jing Li Yongri Jin JeungHoon Lee Mingji Zhu Jinlan Jiang |
| author_facet | Shiyi Wang Rihua Jiang Tianqi Meng Fuqiang Zhang Jing Li Yongri Jin JeungHoon Lee Mingji Zhu Jinlan Jiang |
| author_sort | Shiyi Wang |
| collection | DOAJ |
| description | Abstract Background Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong transdermal ability. Results In a rabbit model of hyperkeratinization, STCM-ATRA-NPs showed significant therapeutic efficacy. By contrast, negative therapeutic efficacy was observed in a golden hamster model of hyper sebum production. Scanning electron microscopy and Fourier transform infrared spectral analyses showed that nanoparticles could penetrate the stratum corneum. Western blotting demonstrated that the nanoparticles could enhance the transdermal efficacy of isotretinoin by reducing the effect of keratin and tight junction proteins. Further, nanoparticles enhanced endocytosis, thereby promoting drug penetration and absorption into the skin. Conclusion STCM-ATRA-NPs were demonstrated to control isotretinoin release, reducing its side effects, and efficiently permeating through the skin by reducing the effect of keratin and tight junction proteins and enhancing endocytosis. |
| first_indexed | 2024-04-14T06:34:07Z |
| format | Article |
| id | doaj.art-e036ee3f67ea414eb9bb7726f47a6bed |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T06:34:07Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-e036ee3f67ea414eb9bb7726f47a6bed2022-12-22T02:07:32ZengBMCJournal of Nanobiotechnology1477-31552020-07-0118111210.1186/s12951-020-00664-9Stem cell membrane-coated isotretinoin for acne treatmentShiyi Wang0Rihua Jiang1Tianqi Meng2Fuqiang Zhang3Jing Li4Yongri Jin5JeungHoon Lee6Mingji Zhu7Jinlan Jiang8Department of Dermatology, China-Japan Union Hospital of Jilin UniversityDepartment of Dermatology, China-Japan Union Hospital of Jilin UniversityDepartment of Dermatology, China-Japan Union Hospital of Jilin UniversityScientific Research Center, China-Japan Union Hospital of Jilin UniversityScientific Research Center, China-Japan Union Hospital of Jilin UniversityCollege of Chemistry, Jilin UniversityDepartment of Dermatology, School of Medicine, Chungnam National UniversityDepartment of Dermatology, China-Japan Union Hospital of Jilin UniversityScientific Research Center, China-Japan Union Hospital of Jilin UniversityAbstract Background Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong transdermal ability. Results In a rabbit model of hyperkeratinization, STCM-ATRA-NPs showed significant therapeutic efficacy. By contrast, negative therapeutic efficacy was observed in a golden hamster model of hyper sebum production. Scanning electron microscopy and Fourier transform infrared spectral analyses showed that nanoparticles could penetrate the stratum corneum. Western blotting demonstrated that the nanoparticles could enhance the transdermal efficacy of isotretinoin by reducing the effect of keratin and tight junction proteins. Further, nanoparticles enhanced endocytosis, thereby promoting drug penetration and absorption into the skin. Conclusion STCM-ATRA-NPs were demonstrated to control isotretinoin release, reducing its side effects, and efficiently permeating through the skin by reducing the effect of keratin and tight junction proteins and enhancing endocytosis.http://link.springer.com/article/10.1186/s12951-020-00664-9Stem cellAcneIsotretinoinTransdermalNanoparticles |
| spellingShingle | Shiyi Wang Rihua Jiang Tianqi Meng Fuqiang Zhang Jing Li Yongri Jin JeungHoon Lee Mingji Zhu Jinlan Jiang Stem cell membrane-coated isotretinoin for acne treatment Journal of Nanobiotechnology Stem cell Acne Isotretinoin Transdermal Nanoparticles |
| title | Stem cell membrane-coated isotretinoin for acne treatment |
| title_full | Stem cell membrane-coated isotretinoin for acne treatment |
| title_fullStr | Stem cell membrane-coated isotretinoin for acne treatment |
| title_full_unstemmed | Stem cell membrane-coated isotretinoin for acne treatment |
| title_short | Stem cell membrane-coated isotretinoin for acne treatment |
| title_sort | stem cell membrane coated isotretinoin for acne treatment |
| topic | Stem cell Acne Isotretinoin Transdermal Nanoparticles |
| url | http://link.springer.com/article/10.1186/s12951-020-00664-9 |
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