Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-Analysis
Although influenza is a major public health concern, little is known about the use of spray live attenuated influenza vaccine (LAIV) among adults. For this reason, we conducted a systematic review and meta-analysis to investigate the efficacy and safety of LAIV, especially in adults with/without cli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/9/998 |
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| author | Giulia Perego Giacomo Pietro Vigezzi Giulia Cocciolo Federica Chiappa Stefano Salvati Federica Balzarini Anna Odone Carlo Signorelli Vincenza Gianfredi |
| author_facet | Giulia Perego Giacomo Pietro Vigezzi Giulia Cocciolo Federica Chiappa Stefano Salvati Federica Balzarini Anna Odone Carlo Signorelli Vincenza Gianfredi |
| author_sort | Giulia Perego |
| collection | DOAJ |
| description | Although influenza is a major public health concern, little is known about the use of spray live attenuated influenza vaccine (LAIV) among adults. For this reason, we conducted a systematic review and meta-analysis to investigate the efficacy and safety of LAIV, especially in adults with/without clinical conditions and children <2 years, with the final aim of possibly extending the clinical indications. PubMed/MEDLINE and Scopus were the two databases consulted through February 2021. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A critical appraisal was conducted. Analyses were performed by using ProMeta3 software. Twenty-two studies were included, showing that LAIV was associated with a higher probability of seroconversion when compared with a placebo and considering the A/H1N1 serotype (pooled OR = 2.26 (95% CI = 1.12–4.54), <i>p</i>-value = 0.022; based on 488 participants, without heterogeneity (I2 = 0.0%)). The meta-analysis also confirmed no significant association with systemic adverse events. Only rhinorrhea, nasal congestion, and sore throat were significantly associated with LAIV compared to the placebo. Despite limited available evidence, LAIV has proved to be a safe and effective flu vaccination, also due to its very low invasiveness, and our review’s results can be considered a starting point for guiding future research and shaping forthcoming vaccination campaigns. |
| first_indexed | 2024-03-10T07:09:07Z |
| format | Article |
| id | doaj.art-e037b9fe9fdc49c6a2e8cf1b00b06bb2 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T07:09:07Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-e037b9fe9fdc49c6a2e8cf1b00b06bb22023-11-22T15:34:38ZengMDPI AGVaccines2076-393X2021-09-019999810.3390/vaccines9090998Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-AnalysisGiulia Perego0Giacomo Pietro Vigezzi1Giulia Cocciolo2Federica Chiappa3Stefano Salvati4Federica Balzarini5Anna Odone6Carlo Signorelli7Vincenza Gianfredi8School of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, ItalySchool of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, ItalySchool of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, ItalySchool of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, ItalySchool of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, ItalyDipartimento per la Programmazione, Accreditamento, Acquisto delle Prestazioni Sanitarie e Sociosanitarie (PAAPSS), Servizio Autorizzazione e Accreditamento, Agenzia di Tutela della Salute (ATS) di Bergamo, Via Galliccioli, 4, 24121 Bergamo, ItalyDepartment of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, ItalySchool of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, ItalySchool of Medicine, Vita-Salute San Raffaele University, Via Olgettina, 58, 20132 Milan, ItalyAlthough influenza is a major public health concern, little is known about the use of spray live attenuated influenza vaccine (LAIV) among adults. For this reason, we conducted a systematic review and meta-analysis to investigate the efficacy and safety of LAIV, especially in adults with/without clinical conditions and children <2 years, with the final aim of possibly extending the clinical indications. PubMed/MEDLINE and Scopus were the two databases consulted through February 2021. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A critical appraisal was conducted. Analyses were performed by using ProMeta3 software. Twenty-two studies were included, showing that LAIV was associated with a higher probability of seroconversion when compared with a placebo and considering the A/H1N1 serotype (pooled OR = 2.26 (95% CI = 1.12–4.54), <i>p</i>-value = 0.022; based on 488 participants, without heterogeneity (I2 = 0.0%)). The meta-analysis also confirmed no significant association with systemic adverse events. Only rhinorrhea, nasal congestion, and sore throat were significantly associated with LAIV compared to the placebo. Despite limited available evidence, LAIV has proved to be a safe and effective flu vaccination, also due to its very low invasiveness, and our review’s results can be considered a starting point for guiding future research and shaping forthcoming vaccination campaigns.https://www.mdpi.com/2076-393X/9/9/998intranasal live attenuated influenza vaccineinactivated influenza vaccineadultinfantimmunogenicityimmune response |
| spellingShingle | Giulia Perego Giacomo Pietro Vigezzi Giulia Cocciolo Federica Chiappa Stefano Salvati Federica Balzarini Anna Odone Carlo Signorelli Vincenza Gianfredi Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-Analysis Vaccines intranasal live attenuated influenza vaccine inactivated influenza vaccine adult infant immunogenicity immune response |
| title | Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-Analysis |
| title_full | Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-Analysis |
| title_fullStr | Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-Analysis |
| title_short | Safety and Efficacy of Spray Intranasal Live Attenuated Influenza Vaccine: Systematic Review and Meta-Analysis |
| title_sort | safety and efficacy of spray intranasal live attenuated influenza vaccine systematic review and meta analysis |
| topic | intranasal live attenuated influenza vaccine inactivated influenza vaccine adult infant immunogenicity immune response |
| url | https://www.mdpi.com/2076-393X/9/9/998 |
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