Clinical and Electrophysiological Prognostic Factors of Childhood Absence Epilepsy
Aim:Childhood absence epilepsy is common idiopathic epilepsy in childhood. This epilepsy, which has been shown to impair cognition, needs to be treated promptly and correctly. Therefore, determining its prognostic factors before treatment can provide prediction on the duration of treatment, drug sel...
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2021-09-01
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| Series: | Journal of Pediatric Research |
| Subjects: | |
| Online Access: |
http://jpedres.org/archives/archive-detail/article-preview/clinical-and-electrophysiological-prognostic-facto/48648
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| _version_ | 1797907047708098560 |
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| author | Hande Gazeteci Tekin Pakize Karaoğlu Pınar Edem |
| author_facet | Hande Gazeteci Tekin Pakize Karaoğlu Pınar Edem |
| author_sort | Hande Gazeteci Tekin |
| collection | DOAJ |
| description | Aim:Childhood absence epilepsy is common idiopathic epilepsy in childhood. This epilepsy, which has been shown to impair cognition, needs to be treated promptly and correctly. Therefore, determining its prognostic factors before treatment can provide prediction on the duration of treatment, drug selection, and drug dosage.Materials and Methods:The electroencephalography (EEG) and clinical findings of patients diagnosed with childhood absence epilepsy who were monitored for at least 12 months in the pediatric neurology clinics of two university hospitals between 2016 and 2020 were reviewed retrospectively. The patients were divided into two groups as responsive and unresponsive, according to seizures, EEG findings, and recurrent seizures after treatment. The epidemiological and clinical features of the two groups were compared.Results:Sixty-three patients who were diagnosed with childhood absence epilepsy according to the Panayiotopoulos criteria participated in this study. Thirty-nine (62%) of the patients were responsive to treatment (group 1), the remaining 24 patients (38%) (group 2) were unresponsive to treatment. Fifteen patients were valproate resistant, and nine patients relapsed after drug treatment withdrawal in group 2. The mean age of the patients was 7.87±1.68. The mean follow-up period was 29.1±13.6 (13-72 months) months. The mean age was lower in the responsive group of patients. The time between the onset of seizures and treatment was significantly longer in group 2. The number of patients with occipital intermittent rhythmic delta activity (OIRDA) in the responsive group was higher. A significant difference was found in the number of spike-slow wave complex and the amplitude of discharges between the two groups.Conclusion:In this study, it was seen that young age was an advantage for treatment response. Early initiation of treatment and OIRDA were good prognostic factors, while high amplitude and numerous discharges were among the poor prognostic factors. |
| first_indexed | 2024-04-10T10:31:28Z |
| format | Article |
| id | doaj.art-e0396029e3fc44d9b1b61be10b6ffdda |
| institution | Directory Open Access Journal |
| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T10:31:28Z |
| publishDate | 2021-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-e0396029e3fc44d9b1b61be10b6ffdda2023-02-15T16:21:08ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782021-09-018332032510.4274/jpr.galenos.2021.9591413049054Clinical and Electrophysiological Prognostic Factors of Childhood Absence EpilepsyHande Gazeteci Tekin0Pakize Karaoğlu1Pınar Edem2 Bakırçay University, Çiğli Training and Research Hospital, Clinic of Pediatrics, Division of Pediatric Neurology, İzmir, Turkey University of Health Sciences Turkey, İzmir Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Clinic of Pediatrics, Division of Pediatric Neurology, İzmir, Turkey Bakırçay University, Çiğli Training and Research Hospital, Clinic of Pediatrics, Division of Pediatric Neurology, İzmir, Turkey Aim:Childhood absence epilepsy is common idiopathic epilepsy in childhood. This epilepsy, which has been shown to impair cognition, needs to be treated promptly and correctly. Therefore, determining its prognostic factors before treatment can provide prediction on the duration of treatment, drug selection, and drug dosage.Materials and Methods:The electroencephalography (EEG) and clinical findings of patients diagnosed with childhood absence epilepsy who were monitored for at least 12 months in the pediatric neurology clinics of two university hospitals between 2016 and 2020 were reviewed retrospectively. The patients were divided into two groups as responsive and unresponsive, according to seizures, EEG findings, and recurrent seizures after treatment. The epidemiological and clinical features of the two groups were compared.Results:Sixty-three patients who were diagnosed with childhood absence epilepsy according to the Panayiotopoulos criteria participated in this study. Thirty-nine (62%) of the patients were responsive to treatment (group 1), the remaining 24 patients (38%) (group 2) were unresponsive to treatment. Fifteen patients were valproate resistant, and nine patients relapsed after drug treatment withdrawal in group 2. The mean age of the patients was 7.87±1.68. The mean follow-up period was 29.1±13.6 (13-72 months) months. The mean age was lower in the responsive group of patients. The time between the onset of seizures and treatment was significantly longer in group 2. The number of patients with occipital intermittent rhythmic delta activity (OIRDA) in the responsive group was higher. A significant difference was found in the number of spike-slow wave complex and the amplitude of discharges between the two groups.Conclusion:In this study, it was seen that young age was an advantage for treatment response. Early initiation of treatment and OIRDA were good prognostic factors, while high amplitude and numerous discharges were among the poor prognostic factors. http://jpedres.org/archives/archive-detail/article-preview/clinical-and-electrophysiological-prognostic-facto/48648 absenceprognostic factorsamplitudeeegresponse |
| spellingShingle | Hande Gazeteci Tekin Pakize Karaoğlu Pınar Edem Clinical and Electrophysiological Prognostic Factors of Childhood Absence Epilepsy Journal of Pediatric Research absence prognostic factors amplitude eeg response |
| title | Clinical and Electrophysiological Prognostic Factors of Childhood Absence Epilepsy |
| title_full | Clinical and Electrophysiological Prognostic Factors of Childhood Absence Epilepsy |
| title_fullStr | Clinical and Electrophysiological Prognostic Factors of Childhood Absence Epilepsy |
| title_full_unstemmed | Clinical and Electrophysiological Prognostic Factors of Childhood Absence Epilepsy |
| title_short | Clinical and Electrophysiological Prognostic Factors of Childhood Absence Epilepsy |
| title_sort | clinical and electrophysiological prognostic factors of childhood absence epilepsy |
| topic | absence prognostic factors amplitude eeg response |
| url |
http://jpedres.org/archives/archive-detail/article-preview/clinical-and-electrophysiological-prognostic-facto/48648
|
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