Study of pH-dependent drugs solubility in water
The solubilities of five sparingly soluble drug-compounds in water have been measured at constant temperatures (298.1K and 310.1K) by the classical saturation shake-flask method. All substances presented in this work are derivatives of anthranilic acid: flufenamic acid, (FLU), mefenamic aci...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Association of the Chemical Engineers of Serbia
2014-01-01
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| Series: | Chemical Industry and Chemical Engineering Quarterly |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/1451-9372/2014/1451-93721200116P.pdf |
| Summary: | The solubilities of five sparingly soluble drug-compounds in water have been
measured at constant temperatures (298.1K and 310.1K) by the classical
saturation shake-flask method. All substances presented in this work are
derivatives of anthranilic acid: flufenamic acid, (FLU), mefenamic acid,
(MEF), niflumic acid, (NIF), diclofenac sodium, (DIC), and meclofenamic
sodium, (MEC). All of them have anti-inflammatory action. Since the aqueous
solubility of the ionized drug is significantly higher than the unionized,
the experimental conditions that affect equilibrium solubility values such as
composition of aqueous buffer have been examined. The Henderson-Hasselbalch
(HH) relationship has been used to predict the pH-dependent solubility
profiles of chosen drugs at two temperatures. For this purpose the pKa values
of the investigated drugs have been determined with Bates-Schwarzenbach
spectrophotometric method at temperature 310.1 K. At temperature 298.1K these
values were reported earlier. Similar values of pKa were obtained from the
solubility measurements. |
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| ISSN: | 1451-9372 2217-7434 |