Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative pathogens for which a solid oral formulation was needed for further...

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Bibliographic Details
Main Authors: Anna K. Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Tilman Aden, Stefan J. Frohberger, Álvaro López Mármol, Dnyaneshwar Kapote, Rolf Jansen, Lillibeth Chaverra-Muñoz, Marc P. Hübner, Kenneth Pfarr, Thomas Hesterkamp, Marc Stadler, Michael Gütschow, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
corallopyronin A (CorA)
antibiotic
anthelmintic
povidone (PVP)
copovidone (PVP/VA)
solubility enhanced formulation
Online Access:https://www.mdpi.com/1999-4923/12/11/1105

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