An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis
Objectives To undertake a comparison of Cal/BDP cream versus foam for the treatment of plaque psoriasis, with cross-trial population differences accounted for. Materials and Methods An anchored matching-adjusted indirect comparison was undertaken, using individual patient data for Cal/BDP cream and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-11-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2022.2116924 |
| _version_ | 1797683505566580736 |
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| author | Anthony Bewley Erin Barker Hannah Baker Will Green Brooke Avey Aina Pi-Blanque Jordi Galván Paw Trebbien Morten Praestegaard |
| author_facet | Anthony Bewley Erin Barker Hannah Baker Will Green Brooke Avey Aina Pi-Blanque Jordi Galván Paw Trebbien Morten Praestegaard |
| author_sort | Anthony Bewley |
| collection | DOAJ |
| description | Objectives To undertake a comparison of Cal/BDP cream versus foam for the treatment of plaque psoriasis, with cross-trial population differences accounted for. Materials and Methods An anchored matching-adjusted indirect comparison was undertaken, using individual patient data for Cal/BDP cream and published aggregated data for Cal/BDP foam. Altogether, 11 outcomes were analyzed, including PGA success, mPASI75, DLQI-related outcomes and treatment satisfaction across numerous domains. For each outcome an odds ratio or mean difference was calculated to represent the relative efficacy of Cal/BDP cream versus foam. Methods were guided by NICE Decision Support Unit recommendations. Results After adjustment, baseline characteristics were balanced across treatment arms in each analysis. There were no statistically significant differences in PGA success, mPASI75 or DLQI outcomes between Cal/BDP cream and foam when they were compared after their recommended treatment durations (8 weeks for cream and 4 weeks for foam). For treatment satisfaction after 1 week of treatment, Cal/BDP cream was significantly superior to the Cal/BDP foam in all but one domain of the questionnaire. Conclusions Cal/BDP cream and Cal/BDP foam have equivalent efficacy and HRQoL (measured in DLQI) outcomes when used for the topical treatment of plaque psoriasis at their recommended treatment durations. A comparison of treatment satisfaction assessments after 1 week of treatment demonstrated that patients find Cal/BDP cream to be more convenient than foam. |
| first_indexed | 2024-03-12T00:15:25Z |
| format | Article |
| id | doaj.art-e03d9345522d401c9b52b595e99aec41 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:15:25Z |
| publishDate | 2022-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-e03d9345522d401c9b52b595e99aec412023-09-15T14:28:52ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-11-013383191319810.1080/09546634.2022.21169242116924An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasisAnthony Bewley0Erin Barker1Hannah Baker2Will Green3Brooke Avey4Aina Pi-Blanque5Jordi Galván6Paw Trebbien7Morten Praestegaard8Barts Health NHS TrustYork Health Economics ConsortiumYork Health Economics ConsortiumYork Health Economics ConsortiumYork Health Economics ConsortiumAlmirallAlmirallMC2 TherapeuticsMC2 TherapeuticsObjectives To undertake a comparison of Cal/BDP cream versus foam for the treatment of plaque psoriasis, with cross-trial population differences accounted for. Materials and Methods An anchored matching-adjusted indirect comparison was undertaken, using individual patient data for Cal/BDP cream and published aggregated data for Cal/BDP foam. Altogether, 11 outcomes were analyzed, including PGA success, mPASI75, DLQI-related outcomes and treatment satisfaction across numerous domains. For each outcome an odds ratio or mean difference was calculated to represent the relative efficacy of Cal/BDP cream versus foam. Methods were guided by NICE Decision Support Unit recommendations. Results After adjustment, baseline characteristics were balanced across treatment arms in each analysis. There were no statistically significant differences in PGA success, mPASI75 or DLQI outcomes between Cal/BDP cream and foam when they were compared after their recommended treatment durations (8 weeks for cream and 4 weeks for foam). For treatment satisfaction after 1 week of treatment, Cal/BDP cream was significantly superior to the Cal/BDP foam in all but one domain of the questionnaire. Conclusions Cal/BDP cream and Cal/BDP foam have equivalent efficacy and HRQoL (measured in DLQI) outcomes when used for the topical treatment of plaque psoriasis at their recommended treatment durations. A comparison of treatment satisfaction assessments after 1 week of treatment demonstrated that patients find Cal/BDP cream to be more convenient than foam.http://dx.doi.org/10.1080/09546634.2022.2116924psoriasismatching-adjusted indirect comparisoncal/bdptopicalspatient-reported outcomes |
| spellingShingle | Anthony Bewley Erin Barker Hannah Baker Will Green Brooke Avey Aina Pi-Blanque Jordi Galván Paw Trebbien Morten Praestegaard An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis Journal of Dermatological Treatment psoriasis matching-adjusted indirect comparison cal/bdp topicals patient-reported outcomes |
| title | An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis |
| title_full | An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis |
| title_fullStr | An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis |
| title_full_unstemmed | An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis |
| title_short | An anchored matching-adjusted indirect comparison of fixed-dose combination calcipotriol and betamethasone dipropionate (Cal/BDP) cream versus Cal/BDP foam for the treatment of psoriasis |
| title_sort | anchored matching adjusted indirect comparison of fixed dose combination calcipotriol and betamethasone dipropionate cal bdp cream versus cal bdp foam for the treatment of psoriasis |
| topic | psoriasis matching-adjusted indirect comparison cal/bdp topicals patient-reported outcomes |
| url | http://dx.doi.org/10.1080/09546634.2022.2116924 |
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