From CPAP to tailored therapy for obstructive sleep Apnoea
Abstract Obstructive Sleep Apnoea (OSA) is a common sleep disorder that is associated with daytime symptoms and a range of comorbidity and mortality. Continuous Positive Airway Pressure (CPAP) therapy is highly efficacious at preventing OSA when in use and has long been the standard treatment for ne...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2018-12-01
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| Series: | Multidisciplinary Respiratory Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40248-018-0157-0 |
| _version_ | 1797285698226618368 |
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| author | Kate Sutherland Kristina Kairaitis Brendon J. Yee Peter A. Cistulli |
| author_facet | Kate Sutherland Kristina Kairaitis Brendon J. Yee Peter A. Cistulli |
| author_sort | Kate Sutherland |
| collection | DOAJ |
| description | Abstract Obstructive Sleep Apnoea (OSA) is a common sleep disorder that is associated with daytime symptoms and a range of comorbidity and mortality. Continuous Positive Airway Pressure (CPAP) therapy is highly efficacious at preventing OSA when in use and has long been the standard treatment for newly diagnosed patients. However, CPAP therapy has well recognised limitations in real world effectiveness due to issues with patient acceptance and suboptimal usage. There is a clear need to enhance OSA treatment strategies and options. Although there are a range of alternative treatments (e.g. weight loss, oral appliances, positional devices, surgery, and emerging therapies such as sedatives and oxygen), generally there are individual differences in efficacy and often OSA will not be completely eliminated. There is increasing recognition that OSA is a heterogeneous disorder in terms of risk factors, clinical presentation, pathophysiology and comorbidity. Better characterisation of OSA heterogeneity will enable tailored approaches to therapy to ensure treatment effectiveness. Tools to elucidate individual anatomical and pathophysiological phenotypes in clinical practice are receiving attention. Additionally, recognising patient preferences, treatment enhancement strategies and broader assessment of treatment effectiveness are part of tailoring therapy at the individual level. This review provides a narrative of current treatment approaches and limitations and the future potential for individual tailoring to enhance treatment effectiveness. |
| first_indexed | 2024-03-07T18:07:01Z |
| format | Article |
| id | doaj.art-e03e93bf08d24066a09f4b3aacba93da |
| institution | Directory Open Access Journal |
| issn | 2049-6958 |
| language | English |
| last_indexed | 2024-03-07T18:07:01Z |
| publishDate | 2018-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Multidisciplinary Respiratory Medicine |
| spelling | doaj.art-e03e93bf08d24066a09f4b3aacba93da2024-03-02T09:07:12ZengPAGEPress PublicationsMultidisciplinary Respiratory Medicine2049-69582018-12-0113111310.1186/s40248-018-0157-0From CPAP to tailored therapy for obstructive sleep ApnoeaKate Sutherland0Kristina Kairaitis1Brendon J. Yee2Peter A. Cistulli3Charles Perkins Centre, The University of SydneyCharles Perkins Centre, The University of SydneyFaculty of Medicine & Health, The University of Sydney School of MedicineCharles Perkins Centre, The University of SydneyAbstract Obstructive Sleep Apnoea (OSA) is a common sleep disorder that is associated with daytime symptoms and a range of comorbidity and mortality. Continuous Positive Airway Pressure (CPAP) therapy is highly efficacious at preventing OSA when in use and has long been the standard treatment for newly diagnosed patients. However, CPAP therapy has well recognised limitations in real world effectiveness due to issues with patient acceptance and suboptimal usage. There is a clear need to enhance OSA treatment strategies and options. Although there are a range of alternative treatments (e.g. weight loss, oral appliances, positional devices, surgery, and emerging therapies such as sedatives and oxygen), generally there are individual differences in efficacy and often OSA will not be completely eliminated. There is increasing recognition that OSA is a heterogeneous disorder in terms of risk factors, clinical presentation, pathophysiology and comorbidity. Better characterisation of OSA heterogeneity will enable tailored approaches to therapy to ensure treatment effectiveness. Tools to elucidate individual anatomical and pathophysiological phenotypes in clinical practice are receiving attention. Additionally, recognising patient preferences, treatment enhancement strategies and broader assessment of treatment effectiveness are part of tailoring therapy at the individual level. This review provides a narrative of current treatment approaches and limitations and the future potential for individual tailoring to enhance treatment effectiveness.http://link.springer.com/article/10.1186/s40248-018-0157-0Obstructive sleep ApnoeaTreatmentContinuous positive airway pressurePersonalised medicinePhenotyping |
| spellingShingle | Kate Sutherland Kristina Kairaitis Brendon J. Yee Peter A. Cistulli From CPAP to tailored therapy for obstructive sleep Apnoea Multidisciplinary Respiratory Medicine Obstructive sleep Apnoea Treatment Continuous positive airway pressure Personalised medicine Phenotyping |
| title | From CPAP to tailored therapy for obstructive sleep Apnoea |
| title_full | From CPAP to tailored therapy for obstructive sleep Apnoea |
| title_fullStr | From CPAP to tailored therapy for obstructive sleep Apnoea |
| title_full_unstemmed | From CPAP to tailored therapy for obstructive sleep Apnoea |
| title_short | From CPAP to tailored therapy for obstructive sleep Apnoea |
| title_sort | from cpap to tailored therapy for obstructive sleep apnoea |
| topic | Obstructive sleep Apnoea Treatment Continuous positive airway pressure Personalised medicine Phenotyping |
| url | http://link.springer.com/article/10.1186/s40248-018-0157-0 |
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