A Drug Repositioning Approach Identifies a Combination of Compounds as a Potential Regimen for Chronic Lymphocytic Leukemia Treatment

A Drug Repositioning Approach Identifies a Combination of Compounds as a Potential Regimen for Chronic Lymphocytic Leukemia Treatment

Drug repositioning is a promising and powerful innovative strategy in the field of drug discovery. In this study, we screened a compound-library containing 800 Food and Drug Administration approved drugs for their anti-leukemic effect. All screening activities made use of human peripheral blood mono...

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Bibliographic Details
Main Authors: Atef Nehdi, Nosaibah Samman, Abdullah Mashhour, Alshaimaa Alhallaj, Thadeo Trivilegio, Sheraz Gul, Jeanette Reinshagen, Ahmed Alaskar, Gamal Gmati, Khadega A. Abuelgasim, Fatmah Mansour, Mohamed Boudjelal
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
CLL
fludarabine
Isoprenaline
ATP depletion
synergistic effect
Ibrutinib
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.579488/full

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