Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry
Carbon monoxide (CO) poisoning is difficult to diagnose owing to its nonspecific symptoms. Multiwave pulse oximetry can be used to quickly screen patients for CO poisoning. However, few studies have analyzed patients with CO poisoning who presented to the emergency department (ED). The primary aim o...
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MDPI AG
2024-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/14/2/168 |
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| author | Jisu Yu Juncheol Lee Yongil Cho Jaehoon Oh Hyunggoo Kang Tae Ho Lim Byuk Sung Ko |
| author_facet | Jisu Yu Juncheol Lee Yongil Cho Jaehoon Oh Hyunggoo Kang Tae Ho Lim Byuk Sung Ko |
| author_sort | Jisu Yu |
| collection | DOAJ |
| description | Carbon monoxide (CO) poisoning is difficult to diagnose owing to its nonspecific symptoms. Multiwave pulse oximetry can be used to quickly screen patients for CO poisoning. However, few studies have analyzed patients with CO poisoning who presented to the emergency department (ED). The primary aim of our study was to determine the correlation between COHb levels measured in blood gas analysis and COHb levels measured in multiwave pulse oximetry. Secondary aims were the sensitivity and specificity of the COHb level cutoff value using multiwave pulse oximetry to predict a 25% COHb level in blood gas analysis. This single-center retrospective observational study included patients with CO poisoning who visited the ED of a university-affiliated hospital in Seoul, Korea between July 2021 and June 2023. COHb poisoning was determined using blood gas analysis and multiwave pulse oximetry. The correlation of COHb levels between the two tests was evaluated using correlation analysis. The area under the receiver operating characteristic curve (AUC) of multiwave pulse oximetry was calculated to predict COHb levels from the blood gas analysis. The optimal cutoff values, sensitivity, and specificity of COHb were determined. A total of 224 patients who had COHb levels measured using both multiwave pulse oximetry and blood gas analysis were included in the analysis. In the correlation analysis, COHb showed a high positive correlation with COHb measured using blood gas analysis (Spearman correlation coefficient = 0.86, <i>p</i> < 0.001). The AUC of COHb measured by multiwave pulse oximetry to predict 25% of the COHb level (which can be an indication of hyperbaric oxygen treatment) measured by blood gas analysis was 0.916. When the COHb levels measured with multiwave pulse oximetry were 20% the sensitivity was 81% and the specificity was 83%, and when the COHb levels were 25% the sensitivity was 50% and the specificity was 95%. The COHb value measured using multiwave pulse oximetry blood gas analysis showed a high correlation. However, additional research using large-scale studies is required for validation. |
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| spelling | doaj.art-e03efe6684c249a8bca00a9a74e594bf2024-02-23T15:23:44ZengMDPI AGJournal of Personalized Medicine2075-44262024-01-0114216810.3390/jpm14020168Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse OximetryJisu Yu0Juncheol Lee1Yongil Cho2Jaehoon Oh3Hyunggoo Kang4Tae Ho Lim5Byuk Sung Ko6Department of Emergency Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Emergency Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Emergency Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Emergency Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Emergency Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Emergency Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of KoreaDepartment of Emergency Medicine, College of Medicine, Hanyang University, Seoul 04763, Republic of KoreaCarbon monoxide (CO) poisoning is difficult to diagnose owing to its nonspecific symptoms. Multiwave pulse oximetry can be used to quickly screen patients for CO poisoning. However, few studies have analyzed patients with CO poisoning who presented to the emergency department (ED). The primary aim of our study was to determine the correlation between COHb levels measured in blood gas analysis and COHb levels measured in multiwave pulse oximetry. Secondary aims were the sensitivity and specificity of the COHb level cutoff value using multiwave pulse oximetry to predict a 25% COHb level in blood gas analysis. This single-center retrospective observational study included patients with CO poisoning who visited the ED of a university-affiliated hospital in Seoul, Korea between July 2021 and June 2023. COHb poisoning was determined using blood gas analysis and multiwave pulse oximetry. The correlation of COHb levels between the two tests was evaluated using correlation analysis. The area under the receiver operating characteristic curve (AUC) of multiwave pulse oximetry was calculated to predict COHb levels from the blood gas analysis. The optimal cutoff values, sensitivity, and specificity of COHb were determined. A total of 224 patients who had COHb levels measured using both multiwave pulse oximetry and blood gas analysis were included in the analysis. In the correlation analysis, COHb showed a high positive correlation with COHb measured using blood gas analysis (Spearman correlation coefficient = 0.86, <i>p</i> < 0.001). The AUC of COHb measured by multiwave pulse oximetry to predict 25% of the COHb level (which can be an indication of hyperbaric oxygen treatment) measured by blood gas analysis was 0.916. When the COHb levels measured with multiwave pulse oximetry were 20% the sensitivity was 81% and the specificity was 83%, and when the COHb levels were 25% the sensitivity was 50% and the specificity was 95%. The COHb value measured using multiwave pulse oximetry blood gas analysis showed a high correlation. However, additional research using large-scale studies is required for validation.https://www.mdpi.com/2075-4426/14/2/168emergency departmentCOHb (carboxyhemoglobin)multiwave pulse oximetrysensitivityspecificity |
| spellingShingle | Jisu Yu Juncheol Lee Yongil Cho Jaehoon Oh Hyunggoo Kang Tae Ho Lim Byuk Sung Ko Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry Journal of Personalized Medicine emergency department COHb (carboxyhemoglobin) multiwave pulse oximetry sensitivity specificity |
| title | Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry |
| title_full | Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry |
| title_fullStr | Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry |
| title_full_unstemmed | Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry |
| title_short | Correlation between Carboxyhemoglobin Levels Measured by Blood Gas Analysis and by Multiwave Pulse Oximetry |
| title_sort | correlation between carboxyhemoglobin levels measured by blood gas analysis and by multiwave pulse oximetry |
| topic | emergency department COHb (carboxyhemoglobin) multiwave pulse oximetry sensitivity specificity |
| url | https://www.mdpi.com/2075-4426/14/2/168 |
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