Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum
Abstract Background Colostrum is the primary source of maternal immunoglobulin A (IgA) for the newborn. IgA participates in protection and regulation mechanisms of the immune response at the neonate’s mucosa. Several studies have evaluated infectious diseases and vaccine protocols effects during pre...
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | Maternal Health, Neonatology and Perinatology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40748-019-0104-x |
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| author | Erick Sánchez-Salguero Geovanni Kaleb Mondragón-Ramírez Julio C. Alcántara-Montiel Arturo Cérbulo-Vázquez Xóchitl Villegas-Domínguez Víctor Manuel Contreras-Vargas María del Rocío Thompson-Bonilla Héctor Romero-Ramírez Leopoldo Santos-Argumedo |
| author_facet | Erick Sánchez-Salguero Geovanni Kaleb Mondragón-Ramírez Julio C. Alcántara-Montiel Arturo Cérbulo-Vázquez Xóchitl Villegas-Domínguez Víctor Manuel Contreras-Vargas María del Rocío Thompson-Bonilla Héctor Romero-Ramírez Leopoldo Santos-Argumedo |
| author_sort | Erick Sánchez-Salguero |
| collection | DOAJ |
| description | Abstract Background Colostrum is the primary source of maternal immunoglobulin A (IgA) for the newborn. IgA participates in protection and regulation mechanisms of the immune response at the neonate’s mucosa. Several studies have evaluated infectious diseases and vaccine protocols effects during pregnancy on maternal milk IgA levels, with the aim to understand lactation protecting effect on newborn. However, most of their results demonstrated that there were no differences in the total IgA levels. In humans, IgA has two subclasses (IgA1 and IgA2), they have an anatomical distribution among mucosal compartments, their levels vary after antigen stimulation and are also seen to describe differential affinities in colostrum. Although there are differences between IgA subclasses in several compartments, these studies have excluded specific colostrum IgA1 and IgA2 determination. Methods We analyzed data from 900 women in Mexico City. With Pearson correlation, we compared the number of infectious episodes during their pregnancy that was associated with mucosal compartments (skin, respiratory and gastrointestinal tracts) and colostrum IgA subclasses. Results We show a correlation between increased colostrum IgA1 levels and the number of infectious episodes at respiratory tract and the skin. In contrast, infections at the gastrointestinal tract correlated with increased IgA2 amounts. Conclusions Infections present during pregnancy at certain mucosal site increase specific IgA subclasses levels in human colostrum. These results will help in understanding infections and immunizations effects on maternal IgA at the mammary gland, and their impact on the development and protection of the newborn. |
| first_indexed | 2024-12-12T11:03:32Z |
| format | Article |
| id | doaj.art-e03f3e5f92eb474381176ed48e72d879 |
| institution | Directory Open Access Journal |
| issn | 2054-958X |
| language | English |
| last_indexed | 2024-12-12T11:03:32Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Maternal Health, Neonatology and Perinatology |
| spelling | doaj.art-e03f3e5f92eb474381176ed48e72d8792022-12-22T00:26:29ZengBMCMaternal Health, Neonatology and Perinatology2054-958X2019-06-01511810.1186/s40748-019-0104-xInfectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrumErick Sánchez-Salguero0Geovanni Kaleb Mondragón-Ramírez1Julio C. Alcántara-Montiel2Arturo Cérbulo-Vázquez3Xóchitl Villegas-Domínguez4Víctor Manuel Contreras-Vargas5María del Rocío Thompson-Bonilla6Héctor Romero-Ramírez7Leopoldo Santos-Argumedo8Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN)Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN)School of Higher Studies Zaragoza, National Autonomous University of Mexico (UNAM), Regional Hospital of High Specialty of Ixtapaluca (HRAEI)Faculty of Medicine, Plan of Combined Studies in Medicine (PECEM), National Autonomous University of Mexico (UNAM)Women’s Hospital, Ministry of Health (SSA)Departments of Gynecology and Genomic Medicine, Regional Hospital 1° de Octubre, Institute of Security and Social Services of State Workers (ISSSTE)Departments of Gynecology and Genomic Medicine, Regional Hospital 1° de Octubre, Institute of Security and Social Services of State Workers (ISSSTE)Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN)Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN)Abstract Background Colostrum is the primary source of maternal immunoglobulin A (IgA) for the newborn. IgA participates in protection and regulation mechanisms of the immune response at the neonate’s mucosa. Several studies have evaluated infectious diseases and vaccine protocols effects during pregnancy on maternal milk IgA levels, with the aim to understand lactation protecting effect on newborn. However, most of their results demonstrated that there were no differences in the total IgA levels. In humans, IgA has two subclasses (IgA1 and IgA2), they have an anatomical distribution among mucosal compartments, their levels vary after antigen stimulation and are also seen to describe differential affinities in colostrum. Although there are differences between IgA subclasses in several compartments, these studies have excluded specific colostrum IgA1 and IgA2 determination. Methods We analyzed data from 900 women in Mexico City. With Pearson correlation, we compared the number of infectious episodes during their pregnancy that was associated with mucosal compartments (skin, respiratory and gastrointestinal tracts) and colostrum IgA subclasses. Results We show a correlation between increased colostrum IgA1 levels and the number of infectious episodes at respiratory tract and the skin. In contrast, infections at the gastrointestinal tract correlated with increased IgA2 amounts. Conclusions Infections present during pregnancy at certain mucosal site increase specific IgA subclasses levels in human colostrum. These results will help in understanding infections and immunizations effects on maternal IgA at the mammary gland, and their impact on the development and protection of the newborn.http://link.springer.com/article/10.1186/s40748-019-0104-xImmunoglobulin AIgA1IgA2Respiratory tractGastrointestinal tractColostrum |
| spellingShingle | Erick Sánchez-Salguero Geovanni Kaleb Mondragón-Ramírez Julio C. Alcántara-Montiel Arturo Cérbulo-Vázquez Xóchitl Villegas-Domínguez Víctor Manuel Contreras-Vargas María del Rocío Thompson-Bonilla Héctor Romero-Ramírez Leopoldo Santos-Argumedo Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum Maternal Health, Neonatology and Perinatology Immunoglobulin A IgA1 IgA2 Respiratory tract Gastrointestinal tract Colostrum |
| title | Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum |
| title_full | Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum |
| title_fullStr | Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum |
| title_full_unstemmed | Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum |
| title_short | Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum |
| title_sort | infectious episodes during pregnancy at particular mucosal sites increase specific iga1 or iga2 subtype levels in human colostrum |
| topic | Immunoglobulin A IgA1 IgA2 Respiratory tract Gastrointestinal tract Colostrum |
| url | http://link.springer.com/article/10.1186/s40748-019-0104-x |
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