Post-operative protein supplementation following orthopaedic surgery: A systematic review
Decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle atrophy. The purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopae...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-03-01
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| Series: | Sports Medicine and Health Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666337623000501 |
| _version_ | 1827338167092510720 |
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| author | Andrew George Brendan M. Holderread Bradley S. Lambert Joshua D. Harris Patrick C. McCulloch |
| author_facet | Andrew George Brendan M. Holderread Bradley S. Lambert Joshua D. Harris Patrick C. McCulloch |
| author_sort | Andrew George |
| collection | DOAJ |
| description | Decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle atrophy. The purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). PubMed (MEDLINE), Embase, Scopus, and Web of Science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic surgery. Two investigators independently conducted the search using relevant Boolean operations. Primary outcomes included functional or physiologic measures of muscle atrophy or strength. Fourteen studies including 611 patients (224 males, 387 females) were analyzed. Three studies evaluated protein supplementation after ACL reconstruction (ACLR), 3 after total hip arthroplasty (THA), 5 after total knee arthroplasty (TKA), and 3 after surgical treatment of hip fracture. Protein supplementation showed beneficial effects across all types of surgery. The primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional area. Multiple authors also demonstrated improved functional measures and quicker achievement of rehabilitation benchmarks. Protein supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLR, THA, TKA, and surgical treatment of hip fracture. These effects often correlate with improved functional measures and quicker achievement of rehabilitation benchmarks. Further research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period. |
| first_indexed | 2024-03-07T19:08:51Z |
| format | Article |
| id | doaj.art-e04039aa2baa4ac1be0879ddc5864b2e |
| institution | Directory Open Access Journal |
| issn | 2666-3376 |
| language | English |
| last_indexed | 2024-03-07T19:08:51Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sports Medicine and Health Science |
| spelling | doaj.art-e04039aa2baa4ac1be0879ddc5864b2e2024-03-01T05:07:19ZengKeAi Communications Co., Ltd.Sports Medicine and Health Science2666-33762024-03-01611624Post-operative protein supplementation following orthopaedic surgery: A systematic reviewAndrew George0Brendan M. Holderread1Bradley S. Lambert2Joshua D. Harris3Patrick C. McCulloch4Houston Methodist Orthopedics and Sports Medicine, 6445 Main Street Suite 2300, Houston, TX, 77030, USAHouston Methodist Orthopedics and Sports Medicine, 6445 Main Street Suite 2300, Houston, TX, 77030, USAHouston Methodist Orthopedics and Sports Medicine, 6445 Main Street Suite 2300, Houston, TX, 77030, USA; Houston Methodist Orthopedic Biomechanics Research Laboratory, 6670 Bertner Ave, Houston, TX, 77030, USA; Corresponding author. Houston Methodist Hospital Outpatient Center, 6445 Main Street, Suite 2500, Houston, TX, 77030, USA.Houston Methodist Orthopedics and Sports Medicine, 6445 Main Street Suite 2300, Houston, TX, 77030, USAHouston Methodist Orthopedics and Sports Medicine, 6445 Main Street Suite 2300, Houston, TX, 77030, USA; Houston Methodist Orthopedic Biomechanics Research Laboratory, 6670 Bertner Ave, Houston, TX, 77030, USADecreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle atrophy. The purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). PubMed (MEDLINE), Embase, Scopus, and Web of Science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic surgery. Two investigators independently conducted the search using relevant Boolean operations. Primary outcomes included functional or physiologic measures of muscle atrophy or strength. Fourteen studies including 611 patients (224 males, 387 females) were analyzed. Three studies evaluated protein supplementation after ACL reconstruction (ACLR), 3 after total hip arthroplasty (THA), 5 after total knee arthroplasty (TKA), and 3 after surgical treatment of hip fracture. Protein supplementation showed beneficial effects across all types of surgery. The primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional area. Multiple authors also demonstrated improved functional measures and quicker achievement of rehabilitation benchmarks. Protein supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following ACLR, THA, TKA, and surgical treatment of hip fracture. These effects often correlate with improved functional measures and quicker achievement of rehabilitation benchmarks. Further research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.http://www.sciencedirect.com/science/article/pii/S2666337623000501Orthopaedic surgeryProtein supplementationSystematic reviewMuscle atrophy |
| spellingShingle | Andrew George Brendan M. Holderread Bradley S. Lambert Joshua D. Harris Patrick C. McCulloch Post-operative protein supplementation following orthopaedic surgery: A systematic review Sports Medicine and Health Science Orthopaedic surgery Protein supplementation Systematic review Muscle atrophy |
| title | Post-operative protein supplementation following orthopaedic surgery: A systematic review |
| title_full | Post-operative protein supplementation following orthopaedic surgery: A systematic review |
| title_fullStr | Post-operative protein supplementation following orthopaedic surgery: A systematic review |
| title_full_unstemmed | Post-operative protein supplementation following orthopaedic surgery: A systematic review |
| title_short | Post-operative protein supplementation following orthopaedic surgery: A systematic review |
| title_sort | post operative protein supplementation following orthopaedic surgery a systematic review |
| topic | Orthopaedic surgery Protein supplementation Systematic review Muscle atrophy |
| url | http://www.sciencedirect.com/science/article/pii/S2666337623000501 |
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