In-silico and in-vitro functional validation of imidazole derivatives as potential sirtuin inhibitor

In-silico and in-vitro functional validation of imidazole derivatives as potential sirtuin inhibitor

IntroductionEpigenetic enzymes can interact with a wide range of genes that actively participate in the progression or repression of a diseased condition, as they are involved in maintaining cellular homeostasis. Sirtuins are a family of Class III epigenetic modifying enzymes that regulate cellular...

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Main Authors: Uma Maheswara Rao Dindi, Suhadha Parveen Sadiq, Sameer Al-Ghamdi, Naif Abdurhman Alrudian, Salman Bin Dayel, Abdulwahab Ali Abuderman, Mohammad Shahid, Thiyagarajan Ramesh, Ravikumar Vilwanathan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Medicine
Subjects:
imidazole
HDAC
inhibitors
epigenetics
sirtuins
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1282820/full

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