Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications
Surgical resection is considered for most brain tumors to obtain tissue diagnosis and to eradicate or debulk the tumor. Glioma, the most common primary malignant brain tumor, generally has a poor prognosis despite the multidisciplinary treatments with radical resection and chemoradiotherapy. Surgica...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2024.1298709/full |
| _version_ | 1797271495145160704 |
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| author | Takenori Shimizu Shota Tanaka Yosuke Kitagawa Yosuke Kitagawa Yusuke Sakaguchi Mako Kamiya Shunsaku Takayanagi Hirokazu Takami Yasuteru Urano Yasuteru Urano Nobuhito Saito |
| author_facet | Takenori Shimizu Shota Tanaka Yosuke Kitagawa Yosuke Kitagawa Yusuke Sakaguchi Mako Kamiya Shunsaku Takayanagi Hirokazu Takami Yasuteru Urano Yasuteru Urano Nobuhito Saito |
| author_sort | Takenori Shimizu |
| collection | DOAJ |
| description | Surgical resection is considered for most brain tumors to obtain tissue diagnosis and to eradicate or debulk the tumor. Glioma, the most common primary malignant brain tumor, generally has a poor prognosis despite the multidisciplinary treatments with radical resection and chemoradiotherapy. Surgical resection of glioma is often complicated by the obscure border between the tumor and the adjacent brain tissues and by the tumor's infiltration into the eloquent brain. 5-aminolevulinic acid is frequently used for tumor visualization, as it exhibits high fluorescence in high-grade glioma. Here, we provide an overview of the fluorescent probes currently used for brain tumors, as well as those under development for other cancers, including HMRG-based probes, 2MeSiR-based probes, and other aminopeptidase probes. We describe our recently developed HMRG-based probes in brain tumors, such as PR-HMRG, combined with the existing diagnosis approach. These probes are remarkably effective for cancer cell recognition. Thus, they can be potentially integrated into surgical treatment for intraoperative detection of cancers. |
| first_indexed | 2024-03-07T14:03:29Z |
| format | Article |
| id | doaj.art-e04246f87365474b96dcadc8e7a7535d |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-03-07T14:03:29Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-e04246f87365474b96dcadc8e7a7535d2024-03-07T04:38:40ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2024-03-011110.3389/fsurg.2024.12987091298709Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applicationsTakenori Shimizu0Shota Tanaka1Yosuke Kitagawa2Yosuke Kitagawa3Yusuke Sakaguchi4Mako Kamiya5Shunsaku Takayanagi6Hirokazu Takami7Yasuteru Urano8Yasuteru Urano9Nobuhito Saito10Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Life Science and Technology, Tokyo Institute of Technology, Tokyo, JapanDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanLaboratory of Chemical Biology and Molecular Imaging, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanLaboratory of Chemistry and Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, JapanDepartment of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanSurgical resection is considered for most brain tumors to obtain tissue diagnosis and to eradicate or debulk the tumor. Glioma, the most common primary malignant brain tumor, generally has a poor prognosis despite the multidisciplinary treatments with radical resection and chemoradiotherapy. Surgical resection of glioma is often complicated by the obscure border between the tumor and the adjacent brain tissues and by the tumor's infiltration into the eloquent brain. 5-aminolevulinic acid is frequently used for tumor visualization, as it exhibits high fluorescence in high-grade glioma. Here, we provide an overview of the fluorescent probes currently used for brain tumors, as well as those under development for other cancers, including HMRG-based probes, 2MeSiR-based probes, and other aminopeptidase probes. We describe our recently developed HMRG-based probes in brain tumors, such as PR-HMRG, combined with the existing diagnosis approach. These probes are remarkably effective for cancer cell recognition. Thus, they can be potentially integrated into surgical treatment for intraoperative detection of cancers.https://www.frontiersin.org/articles/10.3389/fsurg.2024.1298709/fullhydroxymethyl rhodamine greenγ-glutamyl-HMRGglutamylprolyl-HMRGglioblastomaglioma5-aminolevulinic acid |
| spellingShingle | Takenori Shimizu Shota Tanaka Yosuke Kitagawa Yosuke Kitagawa Yusuke Sakaguchi Mako Kamiya Shunsaku Takayanagi Hirokazu Takami Yasuteru Urano Yasuteru Urano Nobuhito Saito Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications Frontiers in Surgery hydroxymethyl rhodamine green γ-glutamyl-HMRG glutamylprolyl-HMRG glioblastoma glioma 5-aminolevulinic acid |
| title | Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications |
| title_full | Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications |
| title_fullStr | Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications |
| title_full_unstemmed | Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications |
| title_short | Advancement of fluorescent aminopeptidase probes for rapid cancer detection–current uses and neurosurgical applications |
| title_sort | advancement of fluorescent aminopeptidase probes for rapid cancer detection current uses and neurosurgical applications |
| topic | hydroxymethyl rhodamine green γ-glutamyl-HMRG glutamylprolyl-HMRG glioblastoma glioma 5-aminolevulinic acid |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2024.1298709/full |
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