Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis
This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Cas...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/10/4/184 |
| _version_ | 1797626568337522688 |
|---|---|
| author | Vanessa Machado João Botelho Joana Lopes Mariana Patrão Ricardo Alves Leandro Chambrone Gil Alcoforado José João Mendes |
| author_facet | Vanessa Machado João Botelho Joana Lopes Mariana Patrão Ricardo Alves Leandro Chambrone Gil Alcoforado José João Mendes |
| author_sort | Vanessa Machado |
| collection | DOAJ |
| description | This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after solid organ transplantation were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Random effects meta-analyses were thoroughly conducted. GRADE assessment provided quality evidence. Four case-control studies fulfilled the inclusion criteria (274 transplant recipients and 146 healthy controls), all of low risk of bias. Meta-analyses revealed significantly higher IL-6 levels in transplanted patients than healthy individuals with low-quality evidence (Mean Difference (MD): 2.55 (95% confidence interval (CI): 2.07, 3.03)). Transplanted patients with periodontitis have higher serum IL-6 levels than transplanted patients without periodontitis with moderate quality evidence (MD: 2.20 (95% CI: 1.00, 3.39)). We found low-quality evidence of higher IL-6 levels than healthy patients in patients with heart and kidney transplant. In these transplanted patients, there was moderate quality evidence that periodontitis is associated with higher IL-6 serum levels. Future research should consider the impact of such a difference in organ failure and systemic complications. |
| first_indexed | 2024-03-11T10:13:16Z |
| format | Article |
| id | doaj.art-e0437efa3ad84ea09b33021156389a19 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T10:13:16Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e0437efa3ad84ea09b33021156389a192023-11-16T14:25:47ZengMDPI AGDiagnostics2075-44182020-03-0110418410.3390/diagnostics10040184Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-AnalysisVanessa Machado0João Botelho1Joana Lopes2Mariana Patrão3Ricardo Alves4Leandro Chambrone5Gil Alcoforado6José João Mendes7Periodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalPeriodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalClinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalClinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalPeriodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalSchool of Dentistry, Ibirapuera University, 04661-100 São Paulo, BrazilPeriodontology Department, Clinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalClinical Research Unit (CRU), Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, 2829-511 Caparica, PortugalThis systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after solid organ transplantation were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Random effects meta-analyses were thoroughly conducted. GRADE assessment provided quality evidence. Four case-control studies fulfilled the inclusion criteria (274 transplant recipients and 146 healthy controls), all of low risk of bias. Meta-analyses revealed significantly higher IL-6 levels in transplanted patients than healthy individuals with low-quality evidence (Mean Difference (MD): 2.55 (95% confidence interval (CI): 2.07, 3.03)). Transplanted patients with periodontitis have higher serum IL-6 levels than transplanted patients without periodontitis with moderate quality evidence (MD: 2.20 (95% CI: 1.00, 3.39)). We found low-quality evidence of higher IL-6 levels than healthy patients in patients with heart and kidney transplant. In these transplanted patients, there was moderate quality evidence that periodontitis is associated with higher IL-6 serum levels. Future research should consider the impact of such a difference in organ failure and systemic complications.https://www.mdpi.com/2075-4418/10/4/184periodontitisperiodontal diseasestransplantationinterleukin-6systematic review |
| spellingShingle | Vanessa Machado João Botelho Joana Lopes Mariana Patrão Ricardo Alves Leandro Chambrone Gil Alcoforado José João Mendes Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis Diagnostics periodontitis periodontal diseases transplantation interleukin-6 systematic review |
| title | Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis |
| title_full | Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis |
| title_short | Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis |
| title_sort | periodontitis impact in interleukin 6 serum levels in solid organ transplanted patients a systematic review and meta analysis |
| topic | periodontitis periodontal diseases transplantation interleukin-6 systematic review |
| url | https://www.mdpi.com/2075-4418/10/4/184 |
| work_keys_str_mv | AT vanessamachado periodontitisimpactininterleukin6serumlevelsinsolidorgantransplantedpatientsasystematicreviewandmetaanalysis AT joaobotelho periodontitisimpactininterleukin6serumlevelsinsolidorgantransplantedpatientsasystematicreviewandmetaanalysis AT joanalopes periodontitisimpactininterleukin6serumlevelsinsolidorgantransplantedpatientsasystematicreviewandmetaanalysis AT marianapatrao periodontitisimpactininterleukin6serumlevelsinsolidorgantransplantedpatientsasystematicreviewandmetaanalysis AT ricardoalves periodontitisimpactininterleukin6serumlevelsinsolidorgantransplantedpatientsasystematicreviewandmetaanalysis AT leandrochambrone periodontitisimpactininterleukin6serumlevelsinsolidorgantransplantedpatientsasystematicreviewandmetaanalysis AT gilalcoforado periodontitisimpactininterleukin6serumlevelsinsolidorgantransplantedpatientsasystematicreviewandmetaanalysis AT josejoaomendes periodontitisimpactininterleukin6serumlevelsinsolidorgantransplantedpatientsasystematicreviewandmetaanalysis |