RSV Induces Activation of Intracellular EGFR on the Mitochondrial Membrane for Virus Propagation
Respiratory syncytial virus (RSV) infects people of all ages and is one of the most common causative agents of lower respiratory tract infections, such as pneumonia, especially in infants under one year of age. However, no direct treatment has been developed for RSV infections. Maintenance of mitoch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/24/17431 |
| _version_ | 1797380729381847040 |
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| author | Se Sil Noh Hye Jin Shin |
| author_facet | Se Sil Noh Hye Jin Shin |
| author_sort | Se Sil Noh |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) infects people of all ages and is one of the most common causative agents of lower respiratory tract infections, such as pneumonia, especially in infants under one year of age. However, no direct treatment has been developed for RSV infections. Maintenance of mitochondrial homeostasis and epidermal growth factor receptor (EGFR) activity is important for human cell growth. This study reported that RSV infection maintained the total cellular ATP levels and promoted the intracellular activity of EGFR to replicate RSV. RSV activates the intracellular EGFR-mediated cell survival signaling cascade and maintains mitochondrial EGFR expression for viral production during early events after infection. The approved EGFR inhibitor, vandetanib, markedly reduces RSV propagation, suggesting that EGFR is an attractive host target for RSV therapeutics. Our results suggest that RSV infection maintains cellular ATP levels and promotes the activation of intracellular EGFR in the mitochondrial membrane, significantly contributing to robust RSV propagation. |
| first_indexed | 2024-03-08T20:42:14Z |
| format | Article |
| id | doaj.art-e043a9ae49144afaa8ecd9403776be53 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T20:42:14Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e043a9ae49144afaa8ecd9403776be532023-12-22T14:14:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124241743110.3390/ijms242417431RSV Induces Activation of Intracellular EGFR on the Mitochondrial Membrane for Virus PropagationSe Sil Noh0Hye Jin Shin1Department of Microbiology, School of Medicine, Chungnam National University, Daejeon 35015, Republic of KoreaDepartment of Microbiology, School of Medicine, Chungnam National University, Daejeon 35015, Republic of KoreaRespiratory syncytial virus (RSV) infects people of all ages and is one of the most common causative agents of lower respiratory tract infections, such as pneumonia, especially in infants under one year of age. However, no direct treatment has been developed for RSV infections. Maintenance of mitochondrial homeostasis and epidermal growth factor receptor (EGFR) activity is important for human cell growth. This study reported that RSV infection maintained the total cellular ATP levels and promoted the intracellular activity of EGFR to replicate RSV. RSV activates the intracellular EGFR-mediated cell survival signaling cascade and maintains mitochondrial EGFR expression for viral production during early events after infection. The approved EGFR inhibitor, vandetanib, markedly reduces RSV propagation, suggesting that EGFR is an attractive host target for RSV therapeutics. Our results suggest that RSV infection maintains cellular ATP levels and promotes the activation of intracellular EGFR in the mitochondrial membrane, significantly contributing to robust RSV propagation.https://www.mdpi.com/1422-0067/24/24/17431intracellular epidermal growth factor receptorvandetanibrespiratory syncytial virusmitochondrial homeostasis |
| spellingShingle | Se Sil Noh Hye Jin Shin RSV Induces Activation of Intracellular EGFR on the Mitochondrial Membrane for Virus Propagation International Journal of Molecular Sciences intracellular epidermal growth factor receptor vandetanib respiratory syncytial virus mitochondrial homeostasis |
| title | RSV Induces Activation of Intracellular EGFR on the Mitochondrial Membrane for Virus Propagation |
| title_full | RSV Induces Activation of Intracellular EGFR on the Mitochondrial Membrane for Virus Propagation |
| title_fullStr | RSV Induces Activation of Intracellular EGFR on the Mitochondrial Membrane for Virus Propagation |
| title_full_unstemmed | RSV Induces Activation of Intracellular EGFR on the Mitochondrial Membrane for Virus Propagation |
| title_short | RSV Induces Activation of Intracellular EGFR on the Mitochondrial Membrane for Virus Propagation |
| title_sort | rsv induces activation of intracellular egfr on the mitochondrial membrane for virus propagation |
| topic | intracellular epidermal growth factor receptor vandetanib respiratory syncytial virus mitochondrial homeostasis |
| url | https://www.mdpi.com/1422-0067/24/24/17431 |
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