Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1

Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1

Abstract We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs28396...

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Main Authors: Xiang Zhou, Seungbin Han, Nadine Cebulla, Larissa Haertle, Maximilian J. Steinhardt, Daniel Schirmer, Eva Runau, Leon Flamm, Calvin Terhorst, Laura Jähnel, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Julia Mersi, Umair Munawar, Magnus Schindehütte, Robert Blum, Ann-Kristin Reinhold, Oliver Scherf-Clavel, Heike L. Rittner, Mirko Pham, Leo Rasche, Hermann Einsele, Claudia Sommer, K. Martin Kortüm
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Biomarker Research
Subjects:
PKNOX1
Multiple myeloma
Bortezomib
Peripheral neuropathy
Online Access:https://doi.org/10.1186/s40364-023-00490-9

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