MicroRNA-mediated gene silencing: are we close to a unifying model?
MicroRNAs (miRNAs) comprise a group of small non-coding RNA –21 nucleotides in length. They act as post-transcriptional regulators of gene expression by forming base pairing interactions with target messenger RNA (mRNA). At least 1000 miRNAs are predicted to be expressed in humans and are encoded fo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2012-02-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc.2011.047 |
| _version_ | 1818689037689421824 |
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| author | James Victoria Wong Sybil C.K. Sharp Tyson V. |
| author_facet | James Victoria Wong Sybil C.K. Sharp Tyson V. |
| author_sort | James Victoria |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) comprise a group of small non-coding RNA –21 nucleotides in length. They act as post-transcriptional regulators of gene expression by forming base pairing interactions with target messenger RNA (mRNA). At least 1000 miRNAs are predicted to be expressed in humans and are encoded for in the genome of almost all organisms. Functional studies indicate that every cellular process studied thus far is regulated at some level by miRNAs. Given this expansive role, it is not surprising that disruption of this crucial pathway underlies the initiation of, or in the least, contributes to the development and progression of numerous human diseases and physiological disorders. This review will focus on the latest developments in uncovering the mechanism(s) of miRNA-mediated silencing with specific reference to the function of terminal effector proteins, how translation of target mRNA is inhibited and whether we are moving towards understanding this fundamental gene silencing paradigm. |
| first_indexed | 2024-12-17T12:03:44Z |
| format | Article |
| id | doaj.art-e049fc4dc2f5448e889858bc100f0e4c |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-17T12:03:44Z |
| publishDate | 2012-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-e049fc4dc2f5448e889858bc100f0e4c2022-12-21T21:49:43ZengDe GruyterBiomolecular Concepts1868-50211868-503X2012-02-0131294010.1515/bmc.2011.047MicroRNA-mediated gene silencing: are we close to a unifying model?James Victoria0Wong Sybil C.K.1Sharp Tyson V.2School of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UKSchool of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UKSchool of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham NG7 2UH, UKMicroRNAs (miRNAs) comprise a group of small non-coding RNA –21 nucleotides in length. They act as post-transcriptional regulators of gene expression by forming base pairing interactions with target messenger RNA (mRNA). At least 1000 miRNAs are predicted to be expressed in humans and are encoded for in the genome of almost all organisms. Functional studies indicate that every cellular process studied thus far is regulated at some level by miRNAs. Given this expansive role, it is not surprising that disruption of this crucial pathway underlies the initiation of, or in the least, contributes to the development and progression of numerous human diseases and physiological disorders. This review will focus on the latest developments in uncovering the mechanism(s) of miRNA-mediated silencing with specific reference to the function of terminal effector proteins, how translation of target mRNA is inhibited and whether we are moving towards understanding this fundamental gene silencing paradigm.https://doi.org/10.1515/bmc.2011.047argonautemicrornasilencingtranslation |
| spellingShingle | James Victoria Wong Sybil C.K. Sharp Tyson V. MicroRNA-mediated gene silencing: are we close to a unifying model? Biomolecular Concepts argonaute microrna silencing translation |
| title | MicroRNA-mediated gene silencing: are we close to a unifying model? |
| title_full | MicroRNA-mediated gene silencing: are we close to a unifying model? |
| title_fullStr | MicroRNA-mediated gene silencing: are we close to a unifying model? |
| title_full_unstemmed | MicroRNA-mediated gene silencing: are we close to a unifying model? |
| title_short | MicroRNA-mediated gene silencing: are we close to a unifying model? |
| title_sort | microrna mediated gene silencing are we close to a unifying model |
| topic | argonaute microrna silencing translation |
| url | https://doi.org/10.1515/bmc.2011.047 |
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