A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer
While proton therapy offers an excellent dose conformity and sparing of organs at risk, this can be compromised by uncertainties, e.g. organ motion. This study aimed to investigate the influence of cardiac motion on the contoured oesophagus using electrocardiogram-triggered imaging and to assess the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Physics and Imaging in Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240563162030052X |
| _version_ | 1819059970144993280 |
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| author | Melissa Thomas Gilles Defraene Mario Levis Edmond Sterpin Maarten Lambrecht Umberto Ricardi Karin Haustermans |
| author_facet | Melissa Thomas Gilles Defraene Mario Levis Edmond Sterpin Maarten Lambrecht Umberto Ricardi Karin Haustermans |
| author_sort | Melissa Thomas |
| collection | DOAJ |
| description | While proton therapy offers an excellent dose conformity and sparing of organs at risk, this can be compromised by uncertainties, e.g. organ motion. This study aimed to investigate the influence of cardiac motion on the contoured oesophagus using electrocardiogram-triggered imaging and to assess the impact of this motion on the robustness of proton therapy plans in oesophageal cancer patients. Limited cardiac-induced motion of the oesophagus was observed with a negligible impact on the robustness of proton therapy plans. Therefore, our data suggest that cardiac motion may be safely ignored in the robust optimisation strategy for proton planning in oesophageal cancer. |
| first_indexed | 2024-12-21T14:19:33Z |
| format | Article |
| id | doaj.art-e04df4da7e2b40bdaee148ee90f30a48 |
| institution | Directory Open Access Journal |
| issn | 2405-6316 |
| language | English |
| last_indexed | 2024-12-21T14:19:33Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Physics and Imaging in Radiation Oncology |
| spelling | doaj.art-e04df4da7e2b40bdaee148ee90f30a482022-12-21T19:00:49ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162020-10-01165053A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancerMelissa Thomas0Gilles Defraene1Mario Levis2Edmond Sterpin3Maarten Lambrecht4Umberto Ricardi5Karin Haustermans6KU Leuven – University of Leuven, Department of Oncology – Laboratory Experimental Radiotherapy, Leuven, Belgium; UZ Leuven – University Hospitals Leuven, Department of Radiation Oncology, Leuven, Belgium; Corresponding author.KU Leuven – University of Leuven, Department of Oncology – Laboratory Experimental Radiotherapy, Leuven, BelgiumUniversity of Torino, Department of Oncology, Torino, ItalyKU Leuven – University of Leuven, Department of Oncology – Laboratory Experimental Radiotherapy, Leuven, Belgium; UCLouvain – Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Center of Molecular Imaging, Radiotherapy and Oncology (MIRO), Sint-Lambrechts-Woluwe, BelgiumKU Leuven – University of Leuven, Department of Oncology – Laboratory Experimental Radiotherapy, Leuven, Belgium; UZ Leuven – University Hospitals Leuven, Department of Radiation Oncology, Leuven, BelgiumUniversity of Torino, Department of Oncology, Torino, ItalyKU Leuven – University of Leuven, Department of Oncology – Laboratory Experimental Radiotherapy, Leuven, Belgium; UZ Leuven – University Hospitals Leuven, Department of Radiation Oncology, Leuven, BelgiumWhile proton therapy offers an excellent dose conformity and sparing of organs at risk, this can be compromised by uncertainties, e.g. organ motion. This study aimed to investigate the influence of cardiac motion on the contoured oesophagus using electrocardiogram-triggered imaging and to assess the impact of this motion on the robustness of proton therapy plans in oesophageal cancer patients. Limited cardiac-induced motion of the oesophagus was observed with a negligible impact on the robustness of proton therapy plans. Therefore, our data suggest that cardiac motion may be safely ignored in the robust optimisation strategy for proton planning in oesophageal cancer.http://www.sciencedirect.com/science/article/pii/S240563162030052XOesophageal cancerCardiac motionProton therapy |
| spellingShingle | Melissa Thomas Gilles Defraene Mario Levis Edmond Sterpin Maarten Lambrecht Umberto Ricardi Karin Haustermans A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer Physics and Imaging in Radiation Oncology Oesophageal cancer Cardiac motion Proton therapy |
| title | A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer |
| title_full | A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer |
| title_fullStr | A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer |
| title_full_unstemmed | A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer |
| title_short | A study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer |
| title_sort | study to investigate the influence of cardiac motion on the robustness of pencil beam scanning proton plans in oesophageal cancer |
| topic | Oesophageal cancer Cardiac motion Proton therapy |
| url | http://www.sciencedirect.com/science/article/pii/S240563162030052X |
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