Nanoparticle-facilitated Functional and Molecular Imaging for the Early Detection of Cancer
Cancer detection in its early stages is imperative for effective cancer treatment and patient survival. In recent years, biomedical imaging techniques, such as magnetic resonance imaging, computed tomography and ultrasound have been greatly developed and have served pivotal roles in clinical cancer...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmolb.2014.00015/full |
| _version_ | 1819059235808346112 |
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| author | Maharajan eSivasubramanian Yu eHsia Leu-Wei eLo |
| author_facet | Maharajan eSivasubramanian Yu eHsia Leu-Wei eLo |
| author_sort | Maharajan eSivasubramanian |
| collection | DOAJ |
| description | Cancer detection in its early stages is imperative for effective cancer treatment and patient survival. In recent years, biomedical imaging techniques, such as magnetic resonance imaging, computed tomography and ultrasound have been greatly developed and have served pivotal roles in clinical cancer management. Molecular imaging (MI) is a non-invasive imaging technique that monitors biological processes at the cellular and sub-cellular levels. To achieve these goals, MI uses targeted imaging agents that can bind targets of interest with high specificity and report on associated abnormalities, a task that cannot be performed by conventional imaging techniques. In this respect, MI holds great promise as a potential therapeutic tool for the early diagnosis of cancer. Nevertheless, the clinical applications of targeted imaging agents are limited due to their inability to overcome biological barriers inside the body. The use of nanoparticles has made it possible to overcome these limitations. Hence, nanoparticles have been the subject of a great deal of recent studies. Therefore, developing nanoparticle-based imaging agents that can target tumors via active or passive targeting mechanisms is desirable. This review focuses on the applications of various functionalized nanoparticle-based imaging agents used in MI for the early detection of cancer. |
| first_indexed | 2024-12-21T14:07:53Z |
| format | Article |
| id | doaj.art-e04e6e2990b5401584f344980c2cdbeb |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-21T14:07:53Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-e04e6e2990b5401584f344980c2cdbeb2022-12-21T19:01:08ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2014-10-01110.3389/fmolb.2014.00015109909Nanoparticle-facilitated Functional and Molecular Imaging for the Early Detection of CancerMaharajan eSivasubramanian0Yu eHsia1Leu-Wei eLo2National Health Research InstitutesNational Health Research InstitutesNational Health Research InstitutesCancer detection in its early stages is imperative for effective cancer treatment and patient survival. In recent years, biomedical imaging techniques, such as magnetic resonance imaging, computed tomography and ultrasound have been greatly developed and have served pivotal roles in clinical cancer management. Molecular imaging (MI) is a non-invasive imaging technique that monitors biological processes at the cellular and sub-cellular levels. To achieve these goals, MI uses targeted imaging agents that can bind targets of interest with high specificity and report on associated abnormalities, a task that cannot be performed by conventional imaging techniques. In this respect, MI holds great promise as a potential therapeutic tool for the early diagnosis of cancer. Nevertheless, the clinical applications of targeted imaging agents are limited due to their inability to overcome biological barriers inside the body. The use of nanoparticles has made it possible to overcome these limitations. Hence, nanoparticles have been the subject of a great deal of recent studies. Therefore, developing nanoparticle-based imaging agents that can target tumors via active or passive targeting mechanisms is desirable. This review focuses on the applications of various functionalized nanoparticle-based imaging agents used in MI for the early detection of cancer.http://journal.frontiersin.org/Journal/10.3389/fmolb.2014.00015/fullGadoliniumMolecular ImagingnanoparticleQuantum dotsgold nanoparticlesIron oxide nanoparticles |
| spellingShingle | Maharajan eSivasubramanian Yu eHsia Leu-Wei eLo Nanoparticle-facilitated Functional and Molecular Imaging for the Early Detection of Cancer Frontiers in Molecular Biosciences Gadolinium Molecular Imaging nanoparticle Quantum dots gold nanoparticles Iron oxide nanoparticles |
| title | Nanoparticle-facilitated Functional and Molecular Imaging for the Early Detection of Cancer |
| title_full | Nanoparticle-facilitated Functional and Molecular Imaging for the Early Detection of Cancer |
| title_fullStr | Nanoparticle-facilitated Functional and Molecular Imaging for the Early Detection of Cancer |
| title_full_unstemmed | Nanoparticle-facilitated Functional and Molecular Imaging for the Early Detection of Cancer |
| title_short | Nanoparticle-facilitated Functional and Molecular Imaging for the Early Detection of Cancer |
| title_sort | nanoparticle facilitated functional and molecular imaging for the early detection of cancer |
| topic | Gadolinium Molecular Imaging nanoparticle Quantum dots gold nanoparticles Iron oxide nanoparticles |
| url | http://journal.frontiersin.org/Journal/10.3389/fmolb.2014.00015/full |
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