Tailored behavioural tests reveal early and progressive cognitive deficits in M1000 prion disease
Prion diseases are pathogenically linked to the normal cellular prion protein (PrPC) misfolding into abnormal conformers (PrPSc), with PrPSc accumulation underpinning both transmission and neurotoxicity. Despite achieving this canonical understanding, however fundamental questions remain incompletel...
Main Authors: | Matteo Senesi, Victoria Lewis, Paul A. Adlard, David I. Finkelstein, Jee Hyun Kim, Steven J. Collins |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-05-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999612300089X |
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