Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Human health risk assessment of chemicals is essential but often relies on time-consuming and animal and labor-extensive procedures. Here, we develop a population-based, quantitative in vitro to in vivo extrapolation (QIVIVE) approach which depended on cellular effects monitored by in vitro assays,...

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Bibliographic Details
Main Authors: Chuanhai Li, Lidan Jiang, Donghui Zhang, Yuan Qi, Xinyi Wang, Yuan Jin, Xinya Liu, Yongfeng Lin, Jiao Luo, Lin Xu, Kunming Zhao, Dianke Yu
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Environment International
Subjects:
6:2 Cl-PFESA
Human health risk assessment
Physiologically based pharmacokinetic (PBPK) modeling
Epigenetic key event
Bioactive equivalent concentration
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412023001198

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