Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review
Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflamm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/7/1559 |
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| author | Mishali AlSharief Esraa Alabdurubalnabi |
| author_facet | Mishali AlSharief Esraa Alabdurubalnabi |
| author_sort | Mishali AlSharief |
| collection | DOAJ |
| description | Periodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflammation, and adverse pregnancy outcomes are no exception. As a result of periodontal pathogen invasion, a series of systemic inflammatory and immunologic events affecting the safety of the fetoplacental unit may unfold. This may be further exaggerated by physiologic hormonal and metabolic fluctuations during pregnancy. This can not only negatively affect the gestation period and consequently cause preterm low weight but also complicate the pregnancy via preeclampsia and gestational diabetes. This narrative review article aims to provide a summary of relevant available evidence pertinent to the relationship between periodontal diseases, associated periodontal pathogens and virulence mechanisms mediated by pro-inflammatory cytokines and prostaglandins, and adverse pregnancy outcomes. Furthermore, this article highlights some of the literature addressing the impact of periodontal therapy interventions and pregnancy outcomes. |
| first_indexed | 2024-03-11T00:54:16Z |
| format | Article |
| id | doaj.art-e05408debc21473ab6f60cb5d1dfb734 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T00:54:16Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-e05408debc21473ab6f60cb5d1dfb7342023-11-18T20:10:12ZengMDPI AGLife2075-17292023-07-01137155910.3390/life13071559Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative ReviewMishali AlSharief0Esraa Alabdurubalnabi1Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaFellowship in Periodontics Program, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaPeriodontal disease is a multi-microbial infection of the teeth-supporting apparatus that manifests as clinical attachment loss and alveolar bone loss. The association between periodontal disease and systemic diseases has been proposed in the literature owing to the former’s chronic state of inflammation, and adverse pregnancy outcomes are no exception. As a result of periodontal pathogen invasion, a series of systemic inflammatory and immunologic events affecting the safety of the fetoplacental unit may unfold. This may be further exaggerated by physiologic hormonal and metabolic fluctuations during pregnancy. This can not only negatively affect the gestation period and consequently cause preterm low weight but also complicate the pregnancy via preeclampsia and gestational diabetes. This narrative review article aims to provide a summary of relevant available evidence pertinent to the relationship between periodontal diseases, associated periodontal pathogens and virulence mechanisms mediated by pro-inflammatory cytokines and prostaglandins, and adverse pregnancy outcomes. Furthermore, this article highlights some of the literature addressing the impact of periodontal therapy interventions and pregnancy outcomes.https://www.mdpi.com/2075-1729/13/7/1559periodontitisperiodontal pathogensoral microbiomeinflammatory mediatorspregnancyadverse pregnancy outcomes |
| spellingShingle | Mishali AlSharief Esraa Alabdurubalnabi Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review Life periodontitis periodontal pathogens oral microbiome inflammatory mediators pregnancy adverse pregnancy outcomes |
| title | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
| title_full | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
| title_fullStr | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
| title_full_unstemmed | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
| title_short | Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review |
| title_sort | periodontal pathogens and adverse pregnancy outcomes a narrative review |
| topic | periodontitis periodontal pathogens oral microbiome inflammatory mediators pregnancy adverse pregnancy outcomes |
| url | https://www.mdpi.com/2075-1729/13/7/1559 |
| work_keys_str_mv | AT mishalialsharief periodontalpathogensandadversepregnancyoutcomesanarrativereview AT esraaalabdurubalnabi periodontalpathogensandadversepregnancyoutcomesanarrativereview |