Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products
The role of eumelanin as a natural pigment in protecting human skin from ultraviolet (UV) light has drawn vast interest in the research and industrial community. Encapsulation of the compound by various shell materials has been extensively studied to optimize and prolong its shielding efficiency fro...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi - SAGE Publishing
2023-01-01
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| Series: | Nanomaterials and Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2023/9832904 |
| _version_ | 1797420589295599616 |
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| author | Oceu Dwi Putri Atitsa Petchsuk Suthawan Buchatip Wilairat Supmak Chariya Kaewsaneha Kamonchanok Thananukul Bunthoeun Nim Sinan Bayram Kanjana Thumanu Pakorn Opaprakasit |
| author_facet | Oceu Dwi Putri Atitsa Petchsuk Suthawan Buchatip Wilairat Supmak Chariya Kaewsaneha Kamonchanok Thananukul Bunthoeun Nim Sinan Bayram Kanjana Thumanu Pakorn Opaprakasit |
| author_sort | Oceu Dwi Putri |
| collection | DOAJ |
| description | The role of eumelanin as a natural pigment in protecting human skin from ultraviolet (UV) light has drawn vast interest in the research and industrial community. Encapsulation of the compound by various shell materials has been extensively studied to optimize and prolong its shielding efficiency from UV penetration through the skin. Polylactide (PLA)-based copolymers have been widely used in the encapsulation of various active compounds due to their biocompatibility and biodegradability that facilitate sustained release of the active compounds. In this work, stereocomplex PLA (sc-PLA) derived from mixtures of poly(D-lactide-caprolactone-D-lactide), P(DLA-b-CL-b-DLA), a triblock copolymer with linear poly(L-lactide), and PLLA are employed to encapsulate eumelanin by an oil-in-water emulsion (O/W) technique. The effect of eumelanin distribution in PLA’s enantiomers and ultrasonication on the physicochemical properties, encapsulation efficiency, and release behavior of the nano/microparticles were evaluated. The potential application of the resulting particles for sunscreen products was assessed in terms of UV absorbance and in vitro sun protection factor (SPF). The nano/microparticles show a hollow spherical structure, whose size can be controlled by ultrasonication. The distribution of eumelanin and the ultrasonication process play a key role in the growth of sc-PLA and the crystalline structure of the particles. The highest encapsulation efficiency of 46.6% was achieved for sc-PLA2U particles. The high content of eumelanin and the hollow structure with a large surface area lead to improvement in the UV absorbance and sunscreen performance of the particles, as revealed by the increase in the SPF value from 9.7 to 16.5. The materials show high potential for various applications, especially in cosmetic and pharmaceutical fields, as UV-shielding products. |
| first_indexed | 2024-03-09T07:03:40Z |
| format | Article |
| id | doaj.art-e0548a72978b4ca98be3324bda65e5ef |
| institution | Directory Open Access Journal |
| issn | 1847-9804 |
| language | English |
| last_indexed | 2024-03-09T07:03:40Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi - SAGE Publishing |
| record_format | Article |
| series | Nanomaterials and Nanotechnology |
| spelling | doaj.art-e0548a72978b4ca98be3324bda65e5ef2023-12-03T09:46:24ZengHindawi - SAGE PublishingNanomaterials and Nanotechnology1847-98042023-01-01202310.1155/2023/9832904Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding ProductsOceu Dwi Putri0Atitsa Petchsuk1Suthawan Buchatip2Wilairat Supmak3Chariya Kaewsaneha4Kamonchanok Thananukul5Bunthoeun Nim6Sinan Bayram7Kanjana Thumanu8Pakorn Opaprakasit9School of Integrated Science and InnovationNational Metal and Materials Technology CenterNational Metal and Materials Technology CenterNational Metal and Materials Technology CenterSchool of Integrated Science and InnovationSchool of Integrated Science and InnovationSchool of Integrated Science and InnovationMedical Laboratory TechniquesSynchrotron Light Research Institute (Public Organization)School of Integrated Science and InnovationThe role of eumelanin as a natural pigment in protecting human skin from ultraviolet (UV) light has drawn vast interest in the research and industrial community. Encapsulation of the compound by various shell materials has been extensively studied to optimize and prolong its shielding efficiency from UV penetration through the skin. Polylactide (PLA)-based copolymers have been widely used in the encapsulation of various active compounds due to their biocompatibility and biodegradability that facilitate sustained release of the active compounds. In this work, stereocomplex PLA (sc-PLA) derived from mixtures of poly(D-lactide-caprolactone-D-lactide), P(DLA-b-CL-b-DLA), a triblock copolymer with linear poly(L-lactide), and PLLA are employed to encapsulate eumelanin by an oil-in-water emulsion (O/W) technique. The effect of eumelanin distribution in PLA’s enantiomers and ultrasonication on the physicochemical properties, encapsulation efficiency, and release behavior of the nano/microparticles were evaluated. The potential application of the resulting particles for sunscreen products was assessed in terms of UV absorbance and in vitro sun protection factor (SPF). The nano/microparticles show a hollow spherical structure, whose size can be controlled by ultrasonication. The distribution of eumelanin and the ultrasonication process play a key role in the growth of sc-PLA and the crystalline structure of the particles. The highest encapsulation efficiency of 46.6% was achieved for sc-PLA2U particles. The high content of eumelanin and the hollow structure with a large surface area lead to improvement in the UV absorbance and sunscreen performance of the particles, as revealed by the increase in the SPF value from 9.7 to 16.5. The materials show high potential for various applications, especially in cosmetic and pharmaceutical fields, as UV-shielding products.http://dx.doi.org/10.1155/2023/9832904 |
| spellingShingle | Oceu Dwi Putri Atitsa Petchsuk Suthawan Buchatip Wilairat Supmak Chariya Kaewsaneha Kamonchanok Thananukul Bunthoeun Nim Sinan Bayram Kanjana Thumanu Pakorn Opaprakasit Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products Nanomaterials and Nanotechnology |
| title | Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products |
| title_full | Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products |
| title_fullStr | Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products |
| title_full_unstemmed | Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products |
| title_short | Preparation of Eumelanin-Encapsulated Stereocomplex Polylactide Nano/Microparticles for Degradable Biocompatible UV-Shielding Products |
| title_sort | preparation of eumelanin encapsulated stereocomplex polylactide nano microparticles for degradable biocompatible uv shielding products |
| url | http://dx.doi.org/10.1155/2023/9832904 |
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