Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes
Abstract Background This study aimed to compare the usefulness of arterial stiffness parameters, cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV), for evaluating arterial damage and risk of cardiovascular disease (CVD) in subjects with diabetes. Methods The study sub...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02800-9 |
| _version_ | 1811215465772482560 |
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| author | Taro Saigusa Kentaro Watanabe Yurika Hada Kota Ishii Wataru Kameda Shinji Susa Kenichi Ishizawa Hisamitsu Ishihara |
| author_facet | Taro Saigusa Kentaro Watanabe Yurika Hada Kota Ishii Wataru Kameda Shinji Susa Kenichi Ishizawa Hisamitsu Ishihara |
| author_sort | Taro Saigusa |
| collection | DOAJ |
| description | Abstract Background This study aimed to compare the usefulness of arterial stiffness parameters, cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV), for evaluating arterial damage and risk of cardiovascular disease (CVD) in subjects with diabetes. Methods The study subjects were 277 patients with type 1 or type 2 diabetes. All subjects were evaluated for vascular stiffness using CAVI (n = 154) or baPWV (n = 123). Carotid intima-media thickness (IMT) and the Suita score were also measured because these are established risk factors for future CVD. Associations of both CAVI and baPWV with these established parameters were evaluated in all subjects, and then in 174 subjects with adjustment for covariates by using propensity score matching. Results In all subjects, CAVI and baPWV correlated significantly with both IMT (r = 0.462, P < 0.001, and r = 0.212, P = 0.019, respectively) and the Suita score (r = 0.573, P < 0.001, and r = 0.373, P < 0.001, respectively). The correlation between CAVI and IMT was more significant than that between baPWV and IMT (Z = 2.33, P = 0.020). Similarly, the correlation between CAVI and the Suita score was more significant than that between baPWV and the Suita score (Z = 2.13, P = 0.033). After adjustment by propensity score matching, significant correlations between CAVI and IMT (r = 0.432 P < 0.001) and between CAVI and the Suita score (r = 0.544, P < 0.001) were preserved, though only the association between baPWV and the Suita score was significant (r = 0.289, P = 0.007) while that between baPWV and IMT showed no significance. Again, CAVI showed a significant association with the Suita score than baPWV (Z = 2.02, P = 0.043). Conclusions CAVI is more closely associated than baPWV with arterial damage and risk of CVD in patients with diabetes. |
| first_indexed | 2024-04-12T06:23:02Z |
| format | Article |
| id | doaj.art-e0564a7fcda64112a745451e640db35d |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-12T06:23:02Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-e0564a7fcda64112a745451e640db35d2022-12-22T03:44:16ZengBMCBMC Cardiovascular Disorders1471-22612022-08-0122111110.1186/s12872-022-02800-9Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetesTaro Saigusa0Kentaro Watanabe1Yurika Hada2Kota Ishii3Wataru Kameda4Shinji Susa5Kenichi Ishizawa6Hisamitsu Ishihara7Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of MedicineDivision of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of MedicineDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of MedicineDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of MedicineDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of MedicineDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of MedicineDepartment of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of MedicineDivision of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of MedicineAbstract Background This study aimed to compare the usefulness of arterial stiffness parameters, cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV), for evaluating arterial damage and risk of cardiovascular disease (CVD) in subjects with diabetes. Methods The study subjects were 277 patients with type 1 or type 2 diabetes. All subjects were evaluated for vascular stiffness using CAVI (n = 154) or baPWV (n = 123). Carotid intima-media thickness (IMT) and the Suita score were also measured because these are established risk factors for future CVD. Associations of both CAVI and baPWV with these established parameters were evaluated in all subjects, and then in 174 subjects with adjustment for covariates by using propensity score matching. Results In all subjects, CAVI and baPWV correlated significantly with both IMT (r = 0.462, P < 0.001, and r = 0.212, P = 0.019, respectively) and the Suita score (r = 0.573, P < 0.001, and r = 0.373, P < 0.001, respectively). The correlation between CAVI and IMT was more significant than that between baPWV and IMT (Z = 2.33, P = 0.020). Similarly, the correlation between CAVI and the Suita score was more significant than that between baPWV and the Suita score (Z = 2.13, P = 0.033). After adjustment by propensity score matching, significant correlations between CAVI and IMT (r = 0.432 P < 0.001) and between CAVI and the Suita score (r = 0.544, P < 0.001) were preserved, though only the association between baPWV and the Suita score was significant (r = 0.289, P = 0.007) while that between baPWV and IMT showed no significance. Again, CAVI showed a significant association with the Suita score than baPWV (Z = 2.02, P = 0.043). Conclusions CAVI is more closely associated than baPWV with arterial damage and risk of CVD in patients with diabetes.https://doi.org/10.1186/s12872-022-02800-9Cardio-ankle vascular indexBrachial-ankle pulse wave velocityArterial damageRisk of cardiovascular disease |
| spellingShingle | Taro Saigusa Kentaro Watanabe Yurika Hada Kota Ishii Wataru Kameda Shinji Susa Kenichi Ishizawa Hisamitsu Ishihara Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes BMC Cardiovascular Disorders Cardio-ankle vascular index Brachial-ankle pulse wave velocity Arterial damage Risk of cardiovascular disease |
| title | Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes |
| title_full | Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes |
| title_fullStr | Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes |
| title_full_unstemmed | Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes |
| title_short | Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes |
| title_sort | cardio ankle vascular index is more closely associated than brachial ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes |
| topic | Cardio-ankle vascular index Brachial-ankle pulse wave velocity Arterial damage Risk of cardiovascular disease |
| url | https://doi.org/10.1186/s12872-022-02800-9 |
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