HIF-1α Induces HECTD2 Up-Regulation and Aggravates the Malignant Progression of Renal Cell Cancer via Repressing miR-320a

HIF-1α Induces HECTD2 Up-Regulation and Aggravates the Malignant Progression of Renal Cell Cancer via Repressing miR-320a

Renal cell carcinoma (RCC) is a frequent malignancy of the urinary system. It has been found that hypoxia mediates the malignant evolvement of RCC. Here, we probe the impact and potential mechanism of HECT domain E3 ubiquitin-protein ligase 2 (HECTD2) and HIF-1α on regulating RCC evolvement. RCC tis...

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Bibliographic Details
Main Authors: Dong Lv, Taimin Shen, Juncheng Yao, Qi Yang, Ying Xiang, Zhiwei Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HIF-1α
HECTD2
MiR-320a
renal cell carcinoma
progression
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.775642/full

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