Full Chromosomal Relationships Between Populations and the Origin of Humans
A comprehensive description of human genomes is essential for understanding human evolution and relationships between modern populations. However, most published literature focuses on local alignment comparison of several genes rather than the complete evolutionary record of individual genomes. Comb...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-02-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.828805/full |
| _version_ | 1798018838484221952 |
|---|---|
| author | Rui Dong Rui Dong Shaojun Pei Mengcen Guan Shek-Chung Yau Changchuan Yin Rong L. He Stephen S.-T. Yau Stephen S.-T. Yau |
| author_facet | Rui Dong Rui Dong Shaojun Pei Mengcen Guan Shek-Chung Yau Changchuan Yin Rong L. He Stephen S.-T. Yau Stephen S.-T. Yau |
| author_sort | Rui Dong |
| collection | DOAJ |
| description | A comprehensive description of human genomes is essential for understanding human evolution and relationships between modern populations. However, most published literature focuses on local alignment comparison of several genes rather than the complete evolutionary record of individual genomes. Combining with data from the 1,000 Genomes Project, we successfully reconstructed 2,504 individual genomes and propose Divided Natural Vector method to analyze the distribution of nucleotides in the genomes. Comparisons based on autosomes, sex chromosomes and mitochondrial genomes reveal the genetic relationships between populations, and different inheritance pattern leads to different phylogenetic results. Results based on mitochondrial genomes confirm the “out-of-Africa” hypothesis and assert that humans, at least females, most likely originated in eastern Africa. The reconstructed genomes are stored on our server and can be further used for any genome-scale analysis of humans (http://yaulab.math.tsinghua.edu.cn/2022_1000genomesprojectdata/). This project provides the complete genomes of thousands of individuals and lays the groundwork for genome-level analyses of the genetic relationships between populations and the origin of humans. |
| first_indexed | 2024-04-11T16:30:51Z |
| format | Article |
| id | doaj.art-e057bd2f54824708b33d80e700c93fd1 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-11T16:30:51Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-e057bd2f54824708b33d80e700c93fd12022-12-22T04:14:03ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-02-011210.3389/fgene.2021.828805828805Full Chromosomal Relationships Between Populations and the Origin of HumansRui Dong0Rui Dong1Shaojun Pei2Mengcen Guan3Shek-Chung Yau4Changchuan Yin5Rong L. He6Stephen S.-T. Yau7Stephen S.-T. Yau8Yau Mathematical Sciences Center, Tsinghua University, Beijing, ChinaYanqi Lake Beijing Institute of Mathematical Sciences and Applications, Beijing, ChinaDepartment of Mathematical Sciences, Tsinghua University, Beijing, ChinaDepartment of Mathematical Sciences, Tsinghua University, Beijing, ChinaInformation Technology Services Center, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, ChinaDepartment of Mathematics, Statistics and Computer Science, University of Illinois at Chicago, Chicago, IL, United StatesDepartment of Biological Sciences, Chicago State University, Chicago, IL, United StatesDepartment of Mathematical Sciences, Tsinghua University, Beijing, ChinaYanqi Lake Beijing Institute of Mathematical Sciences and Applications, Beijing, ChinaA comprehensive description of human genomes is essential for understanding human evolution and relationships between modern populations. However, most published literature focuses on local alignment comparison of several genes rather than the complete evolutionary record of individual genomes. Combining with data from the 1,000 Genomes Project, we successfully reconstructed 2,504 individual genomes and propose Divided Natural Vector method to analyze the distribution of nucleotides in the genomes. Comparisons based on autosomes, sex chromosomes and mitochondrial genomes reveal the genetic relationships between populations, and different inheritance pattern leads to different phylogenetic results. Results based on mitochondrial genomes confirm the “out-of-Africa” hypothesis and assert that humans, at least females, most likely originated in eastern Africa. The reconstructed genomes are stored on our server and can be further used for any genome-scale analysis of humans (http://yaulab.math.tsinghua.edu.cn/2022_1000genomesprojectdata/). This project provides the complete genomes of thousands of individuals and lays the groundwork for genome-level analyses of the genetic relationships between populations and the origin of humans.https://www.frontiersin.org/articles/10.3389/fgene.2021.828805/full1000 genomes projectreconstructed sequencesnatural vectordivided natural vectorpopulation genetics |
| spellingShingle | Rui Dong Rui Dong Shaojun Pei Mengcen Guan Shek-Chung Yau Changchuan Yin Rong L. He Stephen S.-T. Yau Stephen S.-T. Yau Full Chromosomal Relationships Between Populations and the Origin of Humans Frontiers in Genetics 1000 genomes project reconstructed sequences natural vector divided natural vector population genetics |
| title | Full Chromosomal Relationships Between Populations and the Origin of Humans |
| title_full | Full Chromosomal Relationships Between Populations and the Origin of Humans |
| title_fullStr | Full Chromosomal Relationships Between Populations and the Origin of Humans |
| title_full_unstemmed | Full Chromosomal Relationships Between Populations and the Origin of Humans |
| title_short | Full Chromosomal Relationships Between Populations and the Origin of Humans |
| title_sort | full chromosomal relationships between populations and the origin of humans |
| topic | 1000 genomes project reconstructed sequences natural vector divided natural vector population genetics |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.828805/full |
| work_keys_str_mv | AT ruidong fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans AT ruidong fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans AT shaojunpei fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans AT mengcenguan fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans AT shekchungyau fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans AT changchuanyin fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans AT ronglhe fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans AT stephenstyau fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans AT stephenstyau fullchromosomalrelationshipsbetweenpopulationsandtheoriginofhumans |