Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged Rats
Salivary secretion from rat salivary glands occurs in response to stimulation by acetylcholine and norepinephrine released from nerve endings. Aquaporin-5 (AQP5) localizes in lipid rafts under control conditions and is induced to traffic to the apical plasma membrane in interlobular ducts of rat par...
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| Format: | Article |
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Elsevier
2004-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319323382 |
| _version_ | 1818700750022246400 |
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| author | Yasuko Ishikawa Noriko Inoue Yuan Zhenfang Yoshiko Nakae |
| author_facet | Yasuko Ishikawa Noriko Inoue Yuan Zhenfang Yoshiko Nakae |
| author_sort | Yasuko Ishikawa |
| collection | DOAJ |
| description | Salivary secretion from rat salivary glands occurs in response to stimulation by acetylcholine and norepinephrine released from nerve endings. Aquaporin-5 (AQP5) localizes in lipid rafts under control conditions and is induced to traffic to the apical plasma membrane in interlobular ducts of rat parotid glands by the activation of M3 muscarinic acetylcholine receptors or α1-adrenoceptors. This review will focus on the mechanisms of the translocation of AQP5 from lipid rafts to the apical plasma membrane in the interlobular duct cells of parotid glands of normal rats and the impairment of its translocation in diabetic or senescent rats. Keywords:: aquaporin-5, [Ca2+]i, lipid raft, interlobular duct, parotid gland |
| first_indexed | 2024-12-17T15:09:54Z |
| format | Article |
| id | doaj.art-e059e9311e6c4df3b0506683c76da2cb |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-17T15:09:54Z |
| publishDate | 2004-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-e059e9311e6c4df3b0506683c76da2cb2022-12-21T21:43:42ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-01963271275Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged RatsYasuko Ishikawa0Noriko Inoue1Yuan Zhenfang2Yoshiko Nakae3Departments of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, Japan; Corresponding author. FAX: 088-633-7332 E-mail: isikawa@dent.tokushima-u.ac.jpDepartments of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, JapanDepartments of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, JapanDepartments of Oral and Maxillofacial Anatomy, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8504, JapanSalivary secretion from rat salivary glands occurs in response to stimulation by acetylcholine and norepinephrine released from nerve endings. Aquaporin-5 (AQP5) localizes in lipid rafts under control conditions and is induced to traffic to the apical plasma membrane in interlobular ducts of rat parotid glands by the activation of M3 muscarinic acetylcholine receptors or α1-adrenoceptors. This review will focus on the mechanisms of the translocation of AQP5 from lipid rafts to the apical plasma membrane in the interlobular duct cells of parotid glands of normal rats and the impairment of its translocation in diabetic or senescent rats. Keywords:: aquaporin-5, [Ca2+]i, lipid raft, interlobular duct, parotid glandhttp://www.sciencedirect.com/science/article/pii/S1347861319323382 |
| spellingShingle | Yasuko Ishikawa Noriko Inoue Yuan Zhenfang Yoshiko Nakae Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged Rats Journal of Pharmacological Sciences |
| title | Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged Rats |
| title_full | Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged Rats |
| title_fullStr | Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged Rats |
| title_full_unstemmed | Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged Rats |
| title_short | Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: The Translocation of Aquaporin-5 From Lipid Rafts to the Apical Plasma Membranes of Parotid Glands of Normal Rats and the Impairment of It in Diabetic or Aged Rats |
| title_sort | molecular mechanisms and drug development in aquaporin water channel diseases the translocation of aquaporin 5 from lipid rafts to the apical plasma membranes of parotid glands of normal rats and the impairment of it in diabetic or aged rats |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319323382 |
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