Case Report: Successful Treatment With Anti-C5 Monoclonal Antibody in a Japanese Adolescent Who Developed Thrombotic Microangiopathy After Autologous Bone Marrow Transplantation for Malignant Lymphoma

Case Report: Successful Treatment With Anti-C5 Monoclonal Antibody in a Japanese Adolescent Who Developed Thrombotic Microangiopathy After Autologous Bone Marrow Transplantation for Malignant Lymphoma

BackgroundTransplant-associated thrombotic microangiopathy (TA-TMA) is a serious complication of bone marrow transplantation (BMT). Recently, abnormalities in the complement system have been identified in the pathogenesis of TA-TMA, and there are series of reports stating that anti-C5 monoclonal ant...

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Bibliographic Details
Main Authors: Shoichi Shimizu, Tamaki Morohashi, Koji Kanezawa, Hiroshi Yagasaki, Shori Takahashi, Ichiro Morioka
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pediatrics
Subjects:
transplant-associated thrombotic microangiopathy (TA-TMA)
anti-C5 monoclonal antibody (eculizumab)
membrane attack complex (C5b-9)
acute kidney injury (AKI)
graft-versus-host disease (GVHD)
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.908183/full

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https://www.frontiersin.org/articles/10.3389/fped.2022.908183/full

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