Potential key genes involved in metabolic resistance to malathion in the southern house mosquito, Culex quinquefasciatus, and functional validation of CYP325BC1 and CYP9M12 as candidate genes using RNA interference

Potential key genes involved in metabolic resistance to malathion in the southern house mosquito, Culex quinquefasciatus, and functional validation of CYP325BC1 and CYP9M12 as candidate genes using RNA interference

Abstract Background Metabolic detoxification is one of the major mechanisms contributing to the development of resistance in mosquitoes, including the southern house mosquito, Culex quinquefasciatus. The three major detoxification supergene families, cytochrome P450s, glutathione S-transferases and...

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Bibliographic Details
Main Authors: Xinyue Huang, Phillip E. Kaufman, Giridhar N. Athrey, Chris Fredregill, Christina Alvarez, Vinaya Shetty, Michel A. Slotman
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Genomics
Subjects:
Metabolic resistance
Culex quinquefasciatus
Malathion
Cytochrome P450
Transcriptome
RNA interference
Online Access:https://doi.org/10.1186/s12864-023-09241-4

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