Circulating Plasmablasts from Chronically Human Immunodeficiency Virus-Infected Individuals Predominantly Produce Polyreactive/Autoreactive Antibodies

Circulating Plasmablasts from Chronically Human Immunodeficiency Virus-Infected Individuals Predominantly Produce Polyreactive/Autoreactive Antibodies

Understanding the B-cell response during chronic human immunodeficiency virus (HIV) infection is essential for eliciting broad and potent neutralizing antibodies (Abs). In this study, we analyzed the plasmablast repertoire of chronically HIV-infected individuals in combination with antiretroviral th...

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Bibliographic Details
Main Authors:	Hongyan Liao, Yangsheng Yu, Song Li, Yinshi Yue, Chuanmin Tao, Kaihong Su, Zhixin Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-12-01
Series:	Frontiers in Immunology
Subjects:	human immunodeficiency virus B cell plasmablast polyreactive antibody autoreactive antibody Ig heavy
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01691/full

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