Probable role of Brain Natriuretic Peptide (BNP) in lung hypertension secondary to scleroderma
BACKGROUND Scleroderma, when complicated with pulmonary hypertension (PHT), presents a worse prognosis; recently treatment with new drugs seems to offer good perspectives, especially in early diagnosis and treatment. The standard approach for diagnosing PHT consists in measurement of the pulmonary a...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2013-05-01
|
| Series: | Italian Journal of Medicine |
| Subjects: | |
| Online Access: | http://www.italjmed.org/index.php/ijm/article/view/375 |
| _version_ | 1797431043637116928 |
|---|---|
| author | P. Faggioli S. Finazzi E. Vicenzi L. Giani M. Rondena M. Lotzniker A. Mazzone |
| author_facet | P. Faggioli S. Finazzi E. Vicenzi L. Giani M. Rondena M. Lotzniker A. Mazzone |
| author_sort | P. Faggioli |
| collection | DOAJ |
| description | BACKGROUND Scleroderma, when complicated with pulmonary hypertension (PHT), presents a worse prognosis; recently treatment with new drugs seems to offer good perspectives, especially in early diagnosis and treatment. The standard approach for diagnosing PHT consists in measurement of the pulmonary artery pressure (PAP) by means of echodoppler. <br />AIM OF INVESTIGATION Aim of this work is evaluating the significance of the NT-proBNP parameter, matched to echodoppler, in diagnosing scleroderma PHT. <br />MATERIALS AND METHODS Sixty (60) patients, who came to observation for progressive systemic sclerosis underwent echodoppler in order to measure the PAP (normal values up to 30 mmHg). NT-proBNP was determined on serum sample using ECLIA method by Modular E170 (Roche Diagnostics); manufacturer reference values for age and gender were used. Forty-three (43) patients underwent a further NT-proBNP sampling 5 days later in order to assess parameter stability. <br />RESULTS PHT and non- PHT patients showed statistically different (p < 0,001) medians (126 vs 69 pg/ml). No pathologic values of NT-proBNP were measured in the group with PAP < 30 mmHg, while 27% of cases who had PAP between 30 and 40 showed pathologic concentrations. The positivity ratio increases to 57% in patients showing PAP > 40 mmHg. No relevant correlation (r = 0,2) was found between PAP and NT-proBNP. Mean average between the two sampling groups was 31%. <br />CONCLUSIONS In scleroderma patients, combination of NT-proBNP and PAP seems to improve the diagnosis of pulmonary hypertension, especially in presence of borderline pulmonary pressure values. We therefore propose the biochemical observation of NT-proBNP when PAP is > 30 mmHg and in monitoring the evolution of the pathology. |
| first_indexed | 2024-03-09T09:36:16Z |
| format | Article |
| id | doaj.art-e0617547f6af4d46b3830a0624648791 |
| institution | Directory Open Access Journal |
| issn | 1877-9344 1877-9352 |
| language | English |
| last_indexed | 2024-03-09T09:36:16Z |
| publishDate | 2013-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj.art-e0617547f6af4d46b3830a06246487912023-12-02T02:02:13ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522013-05-0111232510.4081/itjm.2007.1.23329Probable role of Brain Natriuretic Peptide (BNP) in lung hypertension secondary to sclerodermaP. FaggioliS. FinazziE. VicenziL. GianiM. RondenaM. LotznikerA. MazzoneBACKGROUND Scleroderma, when complicated with pulmonary hypertension (PHT), presents a worse prognosis; recently treatment with new drugs seems to offer good perspectives, especially in early diagnosis and treatment. The standard approach for diagnosing PHT consists in measurement of the pulmonary artery pressure (PAP) by means of echodoppler. <br />AIM OF INVESTIGATION Aim of this work is evaluating the significance of the NT-proBNP parameter, matched to echodoppler, in diagnosing scleroderma PHT. <br />MATERIALS AND METHODS Sixty (60) patients, who came to observation for progressive systemic sclerosis underwent echodoppler in order to measure the PAP (normal values up to 30 mmHg). NT-proBNP was determined on serum sample using ECLIA method by Modular E170 (Roche Diagnostics); manufacturer reference values for age and gender were used. Forty-three (43) patients underwent a further NT-proBNP sampling 5 days later in order to assess parameter stability. <br />RESULTS PHT and non- PHT patients showed statistically different (p < 0,001) medians (126 vs 69 pg/ml). No pathologic values of NT-proBNP were measured in the group with PAP < 30 mmHg, while 27% of cases who had PAP between 30 and 40 showed pathologic concentrations. The positivity ratio increases to 57% in patients showing PAP > 40 mmHg. No relevant correlation (r = 0,2) was found between PAP and NT-proBNP. Mean average between the two sampling groups was 31%. <br />CONCLUSIONS In scleroderma patients, combination of NT-proBNP and PAP seems to improve the diagnosis of pulmonary hypertension, especially in presence of borderline pulmonary pressure values. We therefore propose the biochemical observation of NT-proBNP when PAP is > 30 mmHg and in monitoring the evolution of the pathology.http://www.italjmed.org/index.php/ijm/article/view/375BNPLung hypertensionScleroderma. |
| spellingShingle | P. Faggioli S. Finazzi E. Vicenzi L. Giani M. Rondena M. Lotzniker A. Mazzone Probable role of Brain Natriuretic Peptide (BNP) in lung hypertension secondary to scleroderma Italian Journal of Medicine BNP Lung hypertension Scleroderma. |
| title | Probable role of Brain Natriuretic Peptide (BNP) in lung hypertension secondary to scleroderma |
| title_full | Probable role of Brain Natriuretic Peptide (BNP) in lung hypertension secondary to scleroderma |
| title_fullStr | Probable role of Brain Natriuretic Peptide (BNP) in lung hypertension secondary to scleroderma |
| title_full_unstemmed | Probable role of Brain Natriuretic Peptide (BNP) in lung hypertension secondary to scleroderma |
| title_short | Probable role of Brain Natriuretic Peptide (BNP) in lung hypertension secondary to scleroderma |
| title_sort | probable role of brain natriuretic peptide bnp in lung hypertension secondary to scleroderma |
| topic | BNP Lung hypertension Scleroderma. |
| url | http://www.italjmed.org/index.php/ijm/article/view/375 |
| work_keys_str_mv | AT pfaggioli probableroleofbrainnatriureticpeptidebnpinlunghypertensionsecondarytoscleroderma AT sfinazzi probableroleofbrainnatriureticpeptidebnpinlunghypertensionsecondarytoscleroderma AT evicenzi probableroleofbrainnatriureticpeptidebnpinlunghypertensionsecondarytoscleroderma AT lgiani probableroleofbrainnatriureticpeptidebnpinlunghypertensionsecondarytoscleroderma AT mrondena probableroleofbrainnatriureticpeptidebnpinlunghypertensionsecondarytoscleroderma AT mlotzniker probableroleofbrainnatriureticpeptidebnpinlunghypertensionsecondarytoscleroderma AT amazzone probableroleofbrainnatriureticpeptidebnpinlunghypertensionsecondarytoscleroderma |