Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review
Cancer poses a serious threat to human health, and the search for safe and effective drugs for its treatment has aroused interest and become a long-term goal. Traditional Chinese herbal medicine (TCM), an ancient science with unique anti-cancer advantages, has achieved outstanding results in long-te...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1159985/full |
| _version_ | 1797857914454540288 |
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| author | Mingtao Zhu Yanping Sun Haodong Bai Yimeng Wang Bingyou Yang Qiuhong Wang Haixue Kuang |
| author_facet | Mingtao Zhu Yanping Sun Haodong Bai Yimeng Wang Bingyou Yang Qiuhong Wang Haixue Kuang |
| author_sort | Mingtao Zhu |
| collection | DOAJ |
| description | Cancer poses a serious threat to human health, and the search for safe and effective drugs for its treatment has aroused interest and become a long-term goal. Traditional Chinese herbal medicine (TCM), an ancient science with unique anti-cancer advantages, has achieved outstanding results in long-term clinical practice. Accumulating evidence shows that saponins are key bioactive components in TCM and have great research and development applications for their significant role in the treatment of cancer. Saponins are a class of glycosides comprising nonpolar triterpenes or sterols attached to hydrophilic oligosaccharide groups that exert antitumor effects by targeting the NF-κB, PI3Ks-Akt-mTOR, MAPK, Wnt-β-catenin, JAK-STAT3, APMK, p53, and EGFR signaling pathways. Presently, few advances have been made in physiological and pathological studies on the effect of saponins on signal transduction pathways involved in cancer treatment. This paper reviews the phytochemistry and extraction methods of saponins of TCM and their effects on signal transduction pathways in cancer. It aims to provide theoretical support for in-depth studies on the anticancer effects of saponins. |
| first_indexed | 2024-04-09T21:04:34Z |
| format | Article |
| id | doaj.art-e0630f42488148d98647cc22bb462341 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T21:04:34Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-e0630f42488148d98647cc22bb4623412023-03-29T04:52:29ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-03-011410.3389/fphar.2023.11599851159985Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A reviewMingtao Zhu0Yanping Sun1Haodong Bai2Yimeng Wang3Bingyou Yang4Qiuhong Wang5Haixue Kuang6Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, ChinaSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, ChinaCancer poses a serious threat to human health, and the search for safe and effective drugs for its treatment has aroused interest and become a long-term goal. Traditional Chinese herbal medicine (TCM), an ancient science with unique anti-cancer advantages, has achieved outstanding results in long-term clinical practice. Accumulating evidence shows that saponins are key bioactive components in TCM and have great research and development applications for their significant role in the treatment of cancer. Saponins are a class of glycosides comprising nonpolar triterpenes or sterols attached to hydrophilic oligosaccharide groups that exert antitumor effects by targeting the NF-κB, PI3Ks-Akt-mTOR, MAPK, Wnt-β-catenin, JAK-STAT3, APMK, p53, and EGFR signaling pathways. Presently, few advances have been made in physiological and pathological studies on the effect of saponins on signal transduction pathways involved in cancer treatment. This paper reviews the phytochemistry and extraction methods of saponins of TCM and their effects on signal transduction pathways in cancer. It aims to provide theoretical support for in-depth studies on the anticancer effects of saponins.https://www.frontiersin.org/articles/10.3389/fphar.2023.1159985/fulltriterpenoid saponinssignal transduction pathwayanti-cancerChinese herbal medicinesteroid saponins |
| spellingShingle | Mingtao Zhu Yanping Sun Haodong Bai Yimeng Wang Bingyou Yang Qiuhong Wang Haixue Kuang Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review Frontiers in Pharmacology triterpenoid saponins signal transduction pathway anti-cancer Chinese herbal medicine steroid saponins |
| title | Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review |
| title_full | Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review |
| title_fullStr | Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review |
| title_full_unstemmed | Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review |
| title_short | Effects of saponins from Chinese herbal medicines on signal transduction pathways in cancer: A review |
| title_sort | effects of saponins from chinese herbal medicines on signal transduction pathways in cancer a review |
| topic | triterpenoid saponins signal transduction pathway anti-cancer Chinese herbal medicine steroid saponins |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1159985/full |
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