Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?
(1) Background: Early identification of mild cognitive impairment (MCI) in people reporting subjective cognitive complaints (SCC) and the study of progression of cognitive decline are important issues in dementia research. This paper examines whether empirically derived procedures predict progressio...
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MDPI AG
2019-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/9/11/314 |
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| author | Eduardo Picón Onésimo Juncos-Rabadán Cristina Lojo-Seoane María Campos-Magdaleno Sabela C. Mallo Ana Nieto-Vietes Arturo X. Pereiro David Facal |
| author_facet | Eduardo Picón Onésimo Juncos-Rabadán Cristina Lojo-Seoane María Campos-Magdaleno Sabela C. Mallo Ana Nieto-Vietes Arturo X. Pereiro David Facal |
| author_sort | Eduardo Picón |
| collection | DOAJ |
| description | (1) Background: Early identification of mild cognitive impairment (MCI) in people reporting subjective cognitive complaints (SCC) and the study of progression of cognitive decline are important issues in dementia research. This paper examines whether empirically derived procedures predict progression from MCI to dementia. (2) Methods: At baseline, 192 participants with SCC were diagnosed according to clinical criteria as cognitively unimpaired (70), single-domain amnestic MCI (65), multiple-domain amnestic MCI (33) and multiple-domain non-amnestic MCI (24). A two-stage hierarchical cluster analysis was performed for empirical classification. Categorical regression analysis was then used to assess the predictive value of the clusters obtained. Participants were re-assessed after 36 months. (3) Results: Participants were grouped into four empirically derived clusters: Cluster 1, similar to multiple-domain amnestic MCI; Cluster 2, characterized by subjective cognitive decline (SCD) but with low scores in language and working memory; Cluster 3, with specific deterioration in episodic memory, similar to single-domain amnestic MCI; and Cluster 4, with SCD but with scores above the mean in all domains. The majority of participants who progressed to dementia were included in Cluster 1. (4) Conclusions: Cluster analysis differentiated between MCI and SCD in a sample of people with SCC and empirical criteria were more closely associated with progression to dementia than standard criteria. |
| first_indexed | 2024-04-13T22:45:04Z |
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| id | doaj.art-e0636dbc3c414c92ae7e0a624bae6cd0 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-13T22:45:04Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-e0636dbc3c414c92ae7e0a624bae6cd02022-12-22T02:26:28ZengMDPI AGBrain Sciences2076-34252019-11-0191131410.3390/brainsci9110314brainsci9110314Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia?Eduardo Picón0Onésimo Juncos-Rabadán1Cristina Lojo-Seoane2María Campos-Magdaleno3Sabela C. Mallo4Ana Nieto-Vietes5Arturo X. Pereiro6David Facal7Department of Methodology of Behavioral Sciences, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, SpainDepartment of Developmental Psychology, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, SpainDepartment of Developmental Psychology, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, SpainDepartment of Developmental Psychology, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, SpainDepartment of Developmental Psychology, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, SpainDepartment of Developmental Psychology, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, SpainDepartment of Developmental Psychology, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, SpainDepartment of Developmental Psychology, University of Santiago de Compostela, Santiago de Compostela, 15782, Galicia, Spain(1) Background: Early identification of mild cognitive impairment (MCI) in people reporting subjective cognitive complaints (SCC) and the study of progression of cognitive decline are important issues in dementia research. This paper examines whether empirically derived procedures predict progression from MCI to dementia. (2) Methods: At baseline, 192 participants with SCC were diagnosed according to clinical criteria as cognitively unimpaired (70), single-domain amnestic MCI (65), multiple-domain amnestic MCI (33) and multiple-domain non-amnestic MCI (24). A two-stage hierarchical cluster analysis was performed for empirical classification. Categorical regression analysis was then used to assess the predictive value of the clusters obtained. Participants were re-assessed after 36 months. (3) Results: Participants were grouped into four empirically derived clusters: Cluster 1, similar to multiple-domain amnestic MCI; Cluster 2, characterized by subjective cognitive decline (SCD) but with low scores in language and working memory; Cluster 3, with specific deterioration in episodic memory, similar to single-domain amnestic MCI; and Cluster 4, with SCD but with scores above the mean in all domains. The majority of participants who progressed to dementia were included in Cluster 1. (4) Conclusions: Cluster analysis differentiated between MCI and SCD in a sample of people with SCC and empirical criteria were more closely associated with progression to dementia than standard criteria.https://www.mdpi.com/2076-3425/9/11/314cognitive agingmild cognitive impairmentsubjective cognitive complaintsdementiacluster analysiscompostela aging studyscreening and diagnosis |
| spellingShingle | Eduardo Picón Onésimo Juncos-Rabadán Cristina Lojo-Seoane María Campos-Magdaleno Sabela C. Mallo Ana Nieto-Vietes Arturo X. Pereiro David Facal Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? Brain Sciences cognitive aging mild cognitive impairment subjective cognitive complaints dementia cluster analysis compostela aging study screening and diagnosis |
| title | Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? |
| title_full | Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? |
| title_fullStr | Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? |
| title_full_unstemmed | Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? |
| title_short | Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? |
| title_sort | does empirically derived classification of individuals with subjective cognitive complaints predict dementia |
| topic | cognitive aging mild cognitive impairment subjective cognitive complaints dementia cluster analysis compostela aging study screening and diagnosis |
| url | https://www.mdpi.com/2076-3425/9/11/314 |
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