SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril)

SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril)

A purified spike (S) glycoprotein of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) coronavirus was used to study its effects on THP-1 macrophages, peripheral blood mononuclear cells (PBMCs), and HUVEC cells. The S protein mediates the entry of SARS-CoV-2 into cells through bin...

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Bibliographic Details
Main Authors: Tlili Barhoumi, Bandar Alghanem, Hayat Shaibah, Fatmah A. Mansour, Hassan S. Alamri, Maaged A. Akiel, Fayhan Alroqi, Mohammad Boudjelal
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
spike protein
monocyte/macrophages
inflammation
angiotensin-converting enzyme inhibitor
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.728896/full

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