Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation
Abstract Background Running with the appropriate intensity may produce a positive influence on the mechanical properties of cortical bone structure. However, few studies have discussed the effects of different running intensities on the mechanical properties at different levels, especially at the mi...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-023-01151-6 |
| _version_ | 1797452068735156224 |
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| author | Ruoxun Fan Jie Liu Zhengbin Jia |
| author_facet | Ruoxun Fan Jie Liu Zhengbin Jia |
| author_sort | Ruoxun Fan |
| collection | DOAJ |
| description | Abstract Background Running with the appropriate intensity may produce a positive influence on the mechanical properties of cortical bone structure. However, few studies have discussed the effects of different running intensities on the mechanical properties at different levels, especially at the micro-level, because the micromechanical parameters are difficult to measure experimentally. Methods An approach that combines finite element analysis and experimental data was proposed to predict a micromechanical parameter in the rat femoral cortical bone structure, namely, the micro-level failure strain. Based on the previous three-point bending experimental information, fracture simulations were performed on the femur finite element models to predict their failure process under the same bending load, and the micro-level failure strains in tension and compression of these models were back-calculated by fitting the experimental load–displacement curves. Then, the effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structure were investigated. Results The micro-level failure strains of the cortical bone structures expressed statistical variations under different running intensities, which indicated that different mechanical stimuli of running had significant influences on the micromechanical properties. The greatest failure strain occurred in the cortical bone structure under low-intensity running, and the lowest failure strain occurred in the structure under high-intensity running. Conclusions Moderate and low-intensity running were effective in enhancing the micromechanical properties, whereas high-intensity running led to the weakening of the micromechanical properties of cortical bone. Based on these, the changing trends in the micromechanical properties were exhibited, and the effects of different running intensities on the fracture performance of rat cortical bone structures could be discussed in combination with the known mechanical parameters at the macro- and nano-levels, which provided the theoretical basis for reducing fracture incidence through running exercise. |
| first_indexed | 2024-03-09T15:03:26Z |
| format | Article |
| id | doaj.art-e06aff71ace64b8abcc0889f9088bafe |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-03-09T15:03:26Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-e06aff71ace64b8abcc0889f9088bafe2023-11-26T13:50:37ZengBMCBioMedical Engineering OnLine1475-925X2023-09-0122111510.1186/s12938-023-01151-6Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigationRuoxun Fan0Jie Liu1Zhengbin Jia2Department of Traffic Engineering, Yangzhou Polytechnic InstituteDepartment of Aerospace Engineering, Jilin Institute of Chemical TechnologyDepartment of Engineering Mechanics, Jilin UniversityAbstract Background Running with the appropriate intensity may produce a positive influence on the mechanical properties of cortical bone structure. However, few studies have discussed the effects of different running intensities on the mechanical properties at different levels, especially at the micro-level, because the micromechanical parameters are difficult to measure experimentally. Methods An approach that combines finite element analysis and experimental data was proposed to predict a micromechanical parameter in the rat femoral cortical bone structure, namely, the micro-level failure strain. Based on the previous three-point bending experimental information, fracture simulations were performed on the femur finite element models to predict their failure process under the same bending load, and the micro-level failure strains in tension and compression of these models were back-calculated by fitting the experimental load–displacement curves. Then, the effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structure were investigated. Results The micro-level failure strains of the cortical bone structures expressed statistical variations under different running intensities, which indicated that different mechanical stimuli of running had significant influences on the micromechanical properties. The greatest failure strain occurred in the cortical bone structure under low-intensity running, and the lowest failure strain occurred in the structure under high-intensity running. Conclusions Moderate and low-intensity running were effective in enhancing the micromechanical properties, whereas high-intensity running led to the weakening of the micromechanical properties of cortical bone. Based on these, the changing trends in the micromechanical properties were exhibited, and the effects of different running intensities on the fracture performance of rat cortical bone structures could be discussed in combination with the known mechanical parameters at the macro- and nano-levels, which provided the theoretical basis for reducing fracture incidence through running exercise.https://doi.org/10.1186/s12938-023-01151-6Cortical boneThree-point bending loadMicro-level failure strainRunning intensityBack-calculation |
| spellingShingle | Ruoxun Fan Jie Liu Zhengbin Jia Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation BioMedical Engineering OnLine Cortical bone Three-point bending load Micro-level failure strain Running intensity Back-calculation |
| title | Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation |
| title_full | Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation |
| title_fullStr | Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation |
| title_full_unstemmed | Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation |
| title_short | Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation |
| title_sort | effects of different running intensities on the micro level failure strain of rat femoral cortical bone structures a finite element investigation |
| topic | Cortical bone Three-point bending load Micro-level failure strain Running intensity Back-calculation |
| url | https://doi.org/10.1186/s12938-023-01151-6 |
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