Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved]
Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-05-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/6-683/v1 |
| _version_ | 1818133101596901376 |
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| author | Terry K. Smith Frédéric Bringaud Derek P. Nolan Luisa M. Figueiredo |
| author_facet | Terry K. Smith Frédéric Bringaud Derek P. Nolan Luisa M. Figueiredo |
| author_sort | Terry K. Smith |
| collection | DOAJ |
| description | Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei, is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism. |
| first_indexed | 2024-12-11T08:47:22Z |
| format | Article |
| id | doaj.art-e06cd16b84364004811a0cb66f951825 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T08:47:22Z |
| publishDate | 2017-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-e06cd16b84364004811a0cb66f9518252022-12-22T01:14:07ZengF1000 Research LtdF1000Research2046-14022017-05-01610.12688/f1000research.10342.111144Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved]Terry K. Smith0Frédéric Bringaud1Derek P. Nolan2Luisa M. Figueiredo3Biomedical Sciences Research Complex, University of St Andrews, Fife, UKLaboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234 CNRS, Université de Bordeaux, Bordeaux, FranceSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, IrelandInstituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, PortugalCellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei, is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.https://f1000research.com/articles/6-683/v1Cellular Microbiology & PathogenesisChemical Biology of the CellMedical MicrobiologyParasitology |
| spellingShingle | Terry K. Smith Frédéric Bringaud Derek P. Nolan Luisa M. Figueiredo Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved] F1000Research Cellular Microbiology & Pathogenesis Chemical Biology of the Cell Medical Microbiology Parasitology |
| title | Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved] |
| title_full | Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved] |
| title_fullStr | Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved] |
| title_full_unstemmed | Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved] |
| title_short | Metabolic reprogramming during the Trypanosoma brucei life cycle [version 1; referees: 4 approved] |
| title_sort | metabolic reprogramming during the trypanosoma brucei life cycle version 1 referees 4 approved |
| topic | Cellular Microbiology & Pathogenesis Chemical Biology of the Cell Medical Microbiology Parasitology |
| url | https://f1000research.com/articles/6-683/v1 |
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