Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging
Abstract Background This study was performed to assess changes in diffusion tensor imaging (DTI) over time in patients with amyotrophic lateral sclerosis (ALS). Methods We performed DTI in 23 ALS patients who had two magnetic resonance imaging (MRI) scans at 6 month intervals and to correlate result...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Medical Imaging |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12880-019-0319-3 |
| _version_ | 1819229862688194560 |
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| author | Ashwag R. Alruwaili Kerstin Pannek Robert D. Henderson Marcus Gray Nyoman D. Kurniawan Pamela A. McCombe |
| author_facet | Ashwag R. Alruwaili Kerstin Pannek Robert D. Henderson Marcus Gray Nyoman D. Kurniawan Pamela A. McCombe |
| author_sort | Ashwag R. Alruwaili |
| collection | DOAJ |
| description | Abstract Background This study was performed to assess changes in diffusion tensor imaging (DTI) over time in patients with amyotrophic lateral sclerosis (ALS). Methods We performed DTI in 23 ALS patients who had two magnetic resonance imaging (MRI) scans at 6 month intervals and to correlate results with clinical features. The revised ALS functional rating scale (ALSFRS–R) was administered at each clinical visit. Data analysis included voxel–based white matter tract–based spatial statistics (TBSS) and atlas–based region–of–interest (ROI) analysis of fractional anisotropy (FA) and mean diffusivity (MD). Results With TBSS, there were no significant changes between the two scans. The average change in FA and MD in the ROIs over 6 months was small and not significant after allowing for multiple comparisons. After allowing for multiple comparisons, there was no significant correlation of FA or MD with ALSFRS–R. Conclusion This study shows that there is little evidence of progressive changes in DTI over time in ALS. This could be because white matter is already substantially damaged by the time of onset of symptoms of ALS. |
| first_indexed | 2024-12-23T11:19:55Z |
| format | Article |
| id | doaj.art-e06d13768ad9403685c8d6d5205db056 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-12-23T11:19:55Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-e06d13768ad9403685c8d6d5205db0562022-12-21T17:49:06ZengBMCBMC Medical Imaging1471-23422019-02-0119111010.1186/s12880-019-0319-3Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imagingAshwag R. Alruwaili0Kerstin Pannek1Robert D. Henderson2Marcus Gray3Nyoman D. Kurniawan4Pamela A. McCombe5Faculty of Medicine, The University of Queensland, Australia and King Saud UniversityThe Australian e-Health Research Centre, CSIRODepartment of Neurology, Faculty of Medicine, Royal Brisbane and Women’s Hospital and The University of QueenslandCentre for Advanced Imaging, The University of QueenslandCentre for Advanced Imaging, The University of QueenslandFaculty of Medicine, UQ Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of QueenslandAbstract Background This study was performed to assess changes in diffusion tensor imaging (DTI) over time in patients with amyotrophic lateral sclerosis (ALS). Methods We performed DTI in 23 ALS patients who had two magnetic resonance imaging (MRI) scans at 6 month intervals and to correlate results with clinical features. The revised ALS functional rating scale (ALSFRS–R) was administered at each clinical visit. Data analysis included voxel–based white matter tract–based spatial statistics (TBSS) and atlas–based region–of–interest (ROI) analysis of fractional anisotropy (FA) and mean diffusivity (MD). Results With TBSS, there were no significant changes between the two scans. The average change in FA and MD in the ROIs over 6 months was small and not significant after allowing for multiple comparisons. After allowing for multiple comparisons, there was no significant correlation of FA or MD with ALSFRS–R. Conclusion This study shows that there is little evidence of progressive changes in DTI over time in ALS. This could be because white matter is already substantially damaged by the time of onset of symptoms of ALS.http://link.springer.com/article/10.1186/s12880-019-0319-3Amyotrophic lateral sclerosisMotor neuron diseaseDiffusion tensor imagingVoxel based morphometryTract-based spatial statisticsCognitive impairment |
| spellingShingle | Ashwag R. Alruwaili Kerstin Pannek Robert D. Henderson Marcus Gray Nyoman D. Kurniawan Pamela A. McCombe Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging BMC Medical Imaging Amyotrophic lateral sclerosis Motor neuron disease Diffusion tensor imaging Voxel based morphometry Tract-based spatial statistics Cognitive impairment |
| title | Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging |
| title_full | Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging |
| title_fullStr | Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging |
| title_full_unstemmed | Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging |
| title_short | Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging |
| title_sort | tract integrity in amyotrophic lateral sclerosis 6 month evaluation using mr diffusion tensor imaging |
| topic | Amyotrophic lateral sclerosis Motor neuron disease Diffusion tensor imaging Voxel based morphometry Tract-based spatial statistics Cognitive impairment |
| url | http://link.springer.com/article/10.1186/s12880-019-0319-3 |
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