Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations
Since late 2019 and early 2020, with the emergence of the COVID-19 pandemic, scientists are rushing to develop treatment and prevention methods to combat SARS-CoV-2. Among these are vaccines. In view of this, the use of animals as experimental models, both to investigate the immunopathology of the d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/12/1/20 |
| _version_ | 1797438012412395520 |
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| author | Gabrielle Gimenes Lima Amanda Izeli Portilho Elizabeth De Gaspari |
| author_facet | Gabrielle Gimenes Lima Amanda Izeli Portilho Elizabeth De Gaspari |
| author_sort | Gabrielle Gimenes Lima |
| collection | DOAJ |
| description | Since late 2019 and early 2020, with the emergence of the COVID-19 pandemic, scientists are rushing to develop treatment and prevention methods to combat SARS-CoV-2. Among these are vaccines. In view of this, the use of animals as experimental models, both to investigate the immunopathology of the disease and to evaluate the efficacy and safety of vaccines, is mandatory. This work aims to describe, through recent scientific articles found in reliable databases, the animal models used for the in vivo testing of COVID-19 vaccines, demonstrating some possibilities of more advantageous/gold-standard models for SARS-CoV-2 vaccines. The majority of the studies use rodents and primates. Meanwhile, the most adequate model to be used as the gold standard for in vivo tests of COVID-19 vaccines is not yet conclusive. Promising options are being discussed as new tests are being carried out and new SARS-CoV-2 variants are emerging. |
| first_indexed | 2024-03-09T11:30:58Z |
| format | Article |
| id | doaj.art-e06d47f4f810436e9dd1561be23b2bec |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T11:30:58Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-e06d47f4f810436e9dd1561be23b2bec2023-11-30T23:52:39ZengMDPI AGPathogens2076-08172022-12-011212010.3390/pathogens12010020Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future ExpectationsGabrielle Gimenes Lima0Amanda Izeli Portilho1Elizabeth De Gaspari2Immunology Center, Adolfo Lutz Institute, São Paulo 01246-902, SP, BrazilImmunology Center, Adolfo Lutz Institute, São Paulo 01246-902, SP, BrazilImmunology Center, Adolfo Lutz Institute, São Paulo 01246-902, SP, BrazilSince late 2019 and early 2020, with the emergence of the COVID-19 pandemic, scientists are rushing to develop treatment and prevention methods to combat SARS-CoV-2. Among these are vaccines. In view of this, the use of animals as experimental models, both to investigate the immunopathology of the disease and to evaluate the efficacy and safety of vaccines, is mandatory. This work aims to describe, through recent scientific articles found in reliable databases, the animal models used for the in vivo testing of COVID-19 vaccines, demonstrating some possibilities of more advantageous/gold-standard models for SARS-CoV-2 vaccines. The majority of the studies use rodents and primates. Meanwhile, the most adequate model to be used as the gold standard for in vivo tests of COVID-19 vaccines is not yet conclusive. Promising options are being discussed as new tests are being carried out and new SARS-CoV-2 variants are emerging.https://www.mdpi.com/2076-0817/12/1/20SARS-CoV-2animal modelvaccinegold standardnew variantscoronavirus |
| spellingShingle | Gabrielle Gimenes Lima Amanda Izeli Portilho Elizabeth De Gaspari Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations Pathogens SARS-CoV-2 animal model vaccine gold standard new variants coronavirus |
| title | Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations |
| title_full | Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations |
| title_fullStr | Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations |
| title_full_unstemmed | Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations |
| title_short | Animal Models to Test SARS-CoV-2 Vaccines: Which Ones Are in Use and Future Expectations |
| title_sort | animal models to test sars cov 2 vaccines which ones are in use and future expectations |
| topic | SARS-CoV-2 animal model vaccine gold standard new variants coronavirus |
| url | https://www.mdpi.com/2076-0817/12/1/20 |
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