Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature
Abstract Background SARS-CoV2 virus could be potentially myopathic. Serum creatinine phosphokinase (CPK) is frequently found elevated in severe SARS-CoV2 infection, which indicates skeletal muscle damage precipitating limb weakness or even ventilatory failure. Case presentation We addressed such a p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-04-01
|
| Series: | Skeletal Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13395-021-00266-5 |
| _version_ | 1818961407014600704 |
|---|---|
| author | Badrul Islam Mohiuddin Ahmed Zhahirul Islam S. M. Begum |
| author_facet | Badrul Islam Mohiuddin Ahmed Zhahirul Islam S. M. Begum |
| author_sort | Badrul Islam |
| collection | DOAJ |
| description | Abstract Background SARS-CoV2 virus could be potentially myopathic. Serum creatinine phosphokinase (CPK) is frequently found elevated in severe SARS-CoV2 infection, which indicates skeletal muscle damage precipitating limb weakness or even ventilatory failure. Case presentation We addressed such a patient in his forties presented with features of severe SARS-CoV2 pneumonia and high serum CPK. He developed severe sepsis and acute respiratory distress syndrome (ARDS) and received intravenous high dose corticosteroid and tocilizumab to counter SARS-CoV2 associated cytokine surge. After 10 days of mechanical ventilation (MV), weaning was unsuccessful albeit apparently clear lung fields, having additionally severe and symmetric limb muscle weakness. Ancillary investigations in addition with serum CPK, including electromyogram, muscle biopsy, and muscle magnetic resonance imaging (MRI) suggested acute myopathy possibly due to skeletal myositis. Conclusion We wish to stress that myopathogenic medication in SARS-CoV2 pneumonia should be used with caution. Additionally, serum CPK could be a potential marker to predict respiratory failure in SARS-CoV2 pneumonia as skeletal myopathy affecting chest muscles may contribute ventilatory failure on top of oxygenation failure due to SARS-CoV2 pneumonia. |
| first_indexed | 2024-12-20T12:12:56Z |
| format | Article |
| id | doaj.art-e06e0798ea8d46d8ab511bd6ed1960e7 |
| institution | Directory Open Access Journal |
| issn | 2044-5040 |
| language | English |
| last_indexed | 2024-12-20T12:12:56Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Skeletal Muscle |
| spelling | doaj.art-e06e0798ea8d46d8ab511bd6ed1960e72022-12-21T19:41:13ZengBMCSkeletal Muscle2044-50402021-04-011111710.1186/s13395-021-00266-5Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literatureBadrul Islam0Mohiuddin Ahmed1Zhahirul Islam2S. M. Begum3Laboratory Sciences and Services Division (LSSD), International Center for Diarrhoeal Disease Research, Bangladesh (icddr,b)Bangladesh Specialized HospitalLaboratory Sciences and Services Division (LSSD), International Center for Diarrhoeal Disease Research, Bangladesh (icddr,b)Bangladesh Specialized HospitalAbstract Background SARS-CoV2 virus could be potentially myopathic. Serum creatinine phosphokinase (CPK) is frequently found elevated in severe SARS-CoV2 infection, which indicates skeletal muscle damage precipitating limb weakness or even ventilatory failure. Case presentation We addressed such a patient in his forties presented with features of severe SARS-CoV2 pneumonia and high serum CPK. He developed severe sepsis and acute respiratory distress syndrome (ARDS) and received intravenous high dose corticosteroid and tocilizumab to counter SARS-CoV2 associated cytokine surge. After 10 days of mechanical ventilation (MV), weaning was unsuccessful albeit apparently clear lung fields, having additionally severe and symmetric limb muscle weakness. Ancillary investigations in addition with serum CPK, including electromyogram, muscle biopsy, and muscle magnetic resonance imaging (MRI) suggested acute myopathy possibly due to skeletal myositis. Conclusion We wish to stress that myopathogenic medication in SARS-CoV2 pneumonia should be used with caution. Additionally, serum CPK could be a potential marker to predict respiratory failure in SARS-CoV2 pneumonia as skeletal myopathy affecting chest muscles may contribute ventilatory failure on top of oxygenation failure due to SARS-CoV2 pneumonia.https://doi.org/10.1186/s13395-021-00266-5MyopathyGuillain-Barré syndromeNerve conductionElectromyogramSARS-CoV2 |
| spellingShingle | Badrul Islam Mohiuddin Ahmed Zhahirul Islam S. M. Begum Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature Skeletal Muscle Myopathy Guillain-Barré syndrome Nerve conduction Electromyogram SARS-CoV2 |
| title | Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature |
| title_full | Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature |
| title_fullStr | Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature |
| title_full_unstemmed | Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature |
| title_short | Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature |
| title_sort | severe acute myopathy following sars cov 2 infection a case report and review of recent literature |
| topic | Myopathy Guillain-Barré syndrome Nerve conduction Electromyogram SARS-CoV2 |
| url | https://doi.org/10.1186/s13395-021-00266-5 |
| work_keys_str_mv | AT badrulislam severeacutemyopathyfollowingsarscov2infectionacasereportandreviewofrecentliterature AT mohiuddinahmed severeacutemyopathyfollowingsarscov2infectionacasereportandreviewofrecentliterature AT zhahirulislam severeacutemyopathyfollowingsarscov2infectionacasereportandreviewofrecentliterature AT smbegum severeacutemyopathyfollowingsarscov2infectionacasereportandreviewofrecentliterature |