Large‐Conductance Calcium‐Activated Potassium Channel Opener, NS1619, Protects Against Mesenteric Artery Remodeling Induced by Agonistic Autoantibodies Against the Angiotensin II Type 1 Receptor

Large‐Conductance Calcium‐Activated Potassium Channel Opener, NS1619, Protects Against Mesenteric Artery Remodeling Induced by Agonistic Autoantibodies Against the Angiotensin II Type 1 Receptor

Background Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1‐AAs) extensively exist in patients with hypertensive diseases and have been demonstrated to play crucial roles in the pathophysiological process of vascular remodeling. However, the treatment options are limited. The...

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Bibliographic Details
Main Authors: Meili Wang, Xiaochen Yin, Shuanglei Li, Xi Zhang, Ming Yi, Chunyu He, Xiaoyue Li, Wei Wang, Suli Zhang, Huirong Liu
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
angiotensin II type 1 receptor
autoantibody
BK channel
NS1619
vascular remodeling
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.024046

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