Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2
Different homologous and heterologous vaccination regimens have been used for COVID-19. Here the authors show in a cohort analysis from Catalonia that heterologous vaccination with ChAdOx1 followed by BNT162b2 has better vaccine effectiveness than two doses of ChAdOx1.
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29301-9 |
| _version_ | 1811335586319958016 |
|---|---|
| author | Eduardo Hermosilla Ermengol Coma Junqing Xie Shuo Feng Carmen Cabezas Leonardo Méndez-Boo Francesc Fina Elisabet Ballo Montserrat Martínez Manuel Medina-Peralta Josep Maria Argimon Daniel Prieto-Alhambra |
| author_facet | Eduardo Hermosilla Ermengol Coma Junqing Xie Shuo Feng Carmen Cabezas Leonardo Méndez-Boo Francesc Fina Elisabet Ballo Montserrat Martínez Manuel Medina-Peralta Josep Maria Argimon Daniel Prieto-Alhambra |
| author_sort | Eduardo Hermosilla |
| collection | DOAJ |
| description | Different homologous and heterologous vaccination regimens have been used for COVID-19. Here the authors show in a cohort analysis from Catalonia that heterologous vaccination with ChAdOx1 followed by BNT162b2 has better vaccine effectiveness than two doses of ChAdOx1. |
| first_indexed | 2024-04-13T17:26:26Z |
| format | Article |
| id | doaj.art-e0705346359f4cfdb2fd32440e604c26 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T17:26:26Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e0705346359f4cfdb2fd32440e604c262022-12-22T02:37:47ZengNature PortfolioNature Communications2041-17232022-03-011311710.1038/s41467-022-29301-9Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2Eduardo Hermosilla0Ermengol Coma1Junqing Xie2Shuo Feng3Carmen Cabezas4Leonardo Méndez-Boo5Francesc Fina6Elisabet Ballo7Montserrat Martínez8Manuel Medina-Peralta9Josep Maria Argimon10Daniel Prieto-Alhambra11Direcció assistencial d’Atenció Primària i a la Comunitat, Institut Català de la Salut (ICS), Generalitat de CatalunyaDirecció assistencial d’Atenció Primària i a la Comunitat, Institut Català de la Salut (ICS), Generalitat de CatalunyaCentre for Statistics in Medicine, NDORMS, University of OxfordOxford Vaccine Group, Department of Paediatrics, University of OxfordPublic Health Secretariat, Department of Health, Generalitat de CatalunyaDirecció assistencial d’Atenció Primària i a la Comunitat, Institut Català de la Salut (ICS), Generalitat de CatalunyaDirecció assistencial d’Atenció Primària i a la Comunitat, Institut Català de la Salut (ICS), Generalitat de CatalunyaDirecció assistencial d’Atenció Primària i a la Comunitat, Institut Català de la Salut (ICS), Generalitat de CatalunyaPublic Health Secretariat, Department of Health, Generalitat de CatalunyaDirecció assistencial d’Atenció Primària i a la Comunitat, Institut Català de la Salut (ICS), Generalitat de CatalunyaPublic Health Secretariat, Department of Health, Generalitat de CatalunyaCentre for Statistics in Medicine, NDORMS, University of OxfordDifferent homologous and heterologous vaccination regimens have been used for COVID-19. Here the authors show in a cohort analysis from Catalonia that heterologous vaccination with ChAdOx1 followed by BNT162b2 has better vaccine effectiveness than two doses of ChAdOx1.https://doi.org/10.1038/s41467-022-29301-9 |
| spellingShingle | Eduardo Hermosilla Ermengol Coma Junqing Xie Shuo Feng Carmen Cabezas Leonardo Méndez-Boo Francesc Fina Elisabet Ballo Montserrat Martínez Manuel Medina-Peralta Josep Maria Argimon Daniel Prieto-Alhambra Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2 Nature Communications |
| title | Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2 |
| title_full | Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2 |
| title_fullStr | Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2 |
| title_full_unstemmed | Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2 |
| title_short | Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2 |
| title_sort | comparative effectiveness and safety of homologous two dose chadox1 versus heterologous vaccination with chadox1 and bnt162b2 |
| url | https://doi.org/10.1038/s41467-022-29301-9 |
| work_keys_str_mv | AT eduardohermosilla comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT ermengolcoma comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT junqingxie comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT shuofeng comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT carmencabezas comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT leonardomendezboo comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT francescfina comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT elisabetballo comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT montserratmartinez comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT manuelmedinaperalta comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT josepmariaargimon comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 AT danielprietoalhambra comparativeeffectivenessandsafetyofhomologoustwodosechadox1versusheterologousvaccinationwithchadox1andbnt162b2 |