Pharmacological inhibition of the SKP2/p300 signaling axis restricts castration-resistant prostate cancer

Pharmacological inhibition of the SKP2/p300 signaling axis restricts castration-resistant prostate cancer

SKP2, an F-box protein of the SCF type of the E3 ubiquitin ligase complex, plays an important function in driving tumorigenesis through the destruction of numerous tumor-suppressive proteins. Besides its critical role in cell cycle regulation, proto-oncogenic functions of SKP2 have also been shown i...

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Bibliographic Details
Main Authors: Abdol-Hossein Rezaeian, Liem Minh Phan, Xiaobo Zhou, Wenyi Wei, Hiroyuki Inuzuka
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
SKP2
p300
Castration-resistant
Prostate cancer
Pharmacological inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558623000155

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