How tissue damage MET metabolism: Regulation of the systemic damage response
Living organisms experience tissue damage from both, the surrounding environment and from inside their bodies. Tissue repair/regeneration is triggered by local tissue injury to restore an injured, or lost, part of the body. Tissue damage results in a series of responses, not only locally but also sy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Fly |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19336934.2016.1221549 |
| _version_ | 1797678390756507648 |
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| author | Soshiro Kashio Fumiaki Obata Masayuki Miura |
| author_facet | Soshiro Kashio Fumiaki Obata Masayuki Miura |
| author_sort | Soshiro Kashio |
| collection | DOAJ |
| description | Living organisms experience tissue damage from both, the surrounding environment and from inside their bodies. Tissue repair/regeneration is triggered by local tissue injury to restore an injured, or lost, part of the body. Tissue damage results in a series of responses, not only locally but also systemically in distant tissues. In our recent publication, we established a “dual system” that induces spatiotemporal tissue damage simultaneously with gene manipulation in surrounding tissues. With this system, we demonstrated that appropriate regulation of methionine metabolism in the fat body is required for tissue repair in Drosophila wing discs, thus highlighting the importance of systemic damage response (SDR) in tissue repair. This “Extra View” aims to discuss our recent reports that propose methionine metabolism to be an essential part of SDR, together with related topics in several model organisms. |
| first_indexed | 2024-03-11T22:59:01Z |
| format | Article |
| id | doaj.art-e0754813af72477e911d04916ed91e72 |
| institution | Directory Open Access Journal |
| issn | 1933-6934 1933-6942 |
| language | English |
| last_indexed | 2024-03-11T22:59:01Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Fly |
| spelling | doaj.art-e0754813af72477e911d04916ed91e722023-09-21T15:09:08ZengTaylor & Francis GroupFly1933-69341933-69422017-01-01111273610.1080/19336934.2016.12215491221549How tissue damage MET metabolism: Regulation of the systemic damage responseSoshiro Kashio0Fumiaki Obata1Masayuki Miura2Graduate School of Pharmaceutical Sciences, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoLiving organisms experience tissue damage from both, the surrounding environment and from inside their bodies. Tissue repair/regeneration is triggered by local tissue injury to restore an injured, or lost, part of the body. Tissue damage results in a series of responses, not only locally but also systemically in distant tissues. In our recent publication, we established a “dual system” that induces spatiotemporal tissue damage simultaneously with gene manipulation in surrounding tissues. With this system, we demonstrated that appropriate regulation of methionine metabolism in the fat body is required for tissue repair in Drosophila wing discs, thus highlighting the importance of systemic damage response (SDR) in tissue repair. This “Extra View” aims to discuss our recent reports that propose methionine metabolism to be an essential part of SDR, together with related topics in several model organisms.http://dx.doi.org/10.1080/19336934.2016.1221549drosophila melanogasterimaginal discmethionine metabolismregenerations-adenosylmethioninesystemic damage responsetissue repair |
| spellingShingle | Soshiro Kashio Fumiaki Obata Masayuki Miura How tissue damage MET metabolism: Regulation of the systemic damage response Fly drosophila melanogaster imaginal disc methionine metabolism regeneration s-adenosylmethionine systemic damage response tissue repair |
| title | How tissue damage MET metabolism: Regulation of the systemic damage response |
| title_full | How tissue damage MET metabolism: Regulation of the systemic damage response |
| title_fullStr | How tissue damage MET metabolism: Regulation of the systemic damage response |
| title_full_unstemmed | How tissue damage MET metabolism: Regulation of the systemic damage response |
| title_short | How tissue damage MET metabolism: Regulation of the systemic damage response |
| title_sort | how tissue damage met metabolism regulation of the systemic damage response |
| topic | drosophila melanogaster imaginal disc methionine metabolism regeneration s-adenosylmethionine systemic damage response tissue repair |
| url | http://dx.doi.org/10.1080/19336934.2016.1221549 |
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